integrin-linked kinase

regulates cell adhesion and anchorage-dependent growth; MW 59 kDa; ILK-2 is an isoform

Also Known As:

ILK protein, human; ILK-2 kinase; ILK1 protein, human; Ilk protein, mouse; Ilk protein, rat; integrin linked kinase, mouse; integrin linked kinase, rat; integrin-linked kinase 1, human; integrin-linked kinase, human; integrin-linked kinase-2; p59 ILK; p59(ILK)

Networked: 443 relevant articles (7 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dedhar, Shoukat: 36 articles (06/2022 - 03/2003)
2.	Wu, Chuanyue: 13 articles (02/2013 - 08/2002)
3.	Li, Gang: 9 articles (12/2016 - 10/2003)
4.	Chen, Ching-Shih: 8 articles (11/2018 - 09/2011)
5.	Xu, Biao: 8 articles (05/2017 - 09/2009)
6.	Dedhar, S: 8 articles (02/2011 - 03/2000)
7.	McDonald, Paul C: 7 articles (06/2022 - 01/2006)
8.	Bravou, Vasiliki: 7 articles (01/2021 - 11/2008)
9.	Papadaki, Helen: 7 articles (01/2021 - 11/2008)
10.	Hannigan, Gregory: 7 articles (01/2013 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2021 - "Further studies demonstrated that LGF-500-induced suppression of YAP activation was mediated by integrin-linked kinase (ILK), suggesting that the ILK/YAP axis might be feasible target for anti-EMT and antimetastatic treatments, which was verified by a correlation analysis with clinical data and tumor specimens. " 02/22/2021 - "In this study, in metastatic breast (MDA-MB-231) and prostate (PC-3) cancer cells, we report that integrin-linked kinase (ILK) integrates β1-integrin with this signaling complex to regulate invadopodia activity and invasion. " 03/01/2013 - "Recent studies have also shown that the down-regulation of integrin-linked kinase has anti-tumor potential by inhibiting the metastatic potential of several types of cultured human cancer cells. " 06/25/2023 - "In cancer cells, inhibition of integrin-linked kinase (ILK) increases centrosome declustering causing mitotic arrest and cell death. " 01/01/2022 - "miR-542-3p is a negative regulator of CRC, while integrin-linked kinase could contribute to tumor progression and chemoresistance. "
2.	Myocardial Infarction 05/01/2017 - "Previous studies have described the beneficial effects of overexpressing integrin-linked kinase (ILK) after myocardial infarction (MI) in small animal models. " 01/01/2023 - "α1A Adrenoreceptor blockade attenuates myocardial infarction by modulating the integrin-linked kinase/TGF-β/Smad signaling pathways." 05/01/2017 - "Expression of integrin-linked kinase improves cardiac function in a swine model of myocardial infarction." 08/01/2014 - "To evaluate whether gender influences left ventricular (LV) remodeling and integrin-linked kinase (ILK) after myocardial infarction (MI). " 09/01/2009 - "Here we investigated whether integrin-linked kinase (ILK) may regulate LV remodeling and function after myocardial infarction. "
3.	Neoplasm Metastasis (Metastasis) 02/01/2022 - "In many studies, miR-625-5p has been shown to inhibit downstream pathways from affecting the metastasis and invasion of the integrin-linked kinase (ILK) signaling pathway. " 01/01/2012 - "Recent studies have shown that integrin-linked kinase (ILK) is involved in metastasis of human tumors, expression silencing of ILK inhibiting the metastasis of several types of cultured human cancer cells. " 05/01/2023 - "Integrin-linked kinase (ILK) signaling plays key a role in tumor progression including metastasis, proliferation and migration. " 06/30/2022 - "New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis." 02/01/2021 - "Downregulation of PARVA promotes metastasis by modulating integrin-linked kinase activity and regulating MAPK/ERK and MLC2 signaling in prostate cancer."
4.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "A CRISPR-Cas9 screen reveals that loss of integrin-linked kinase synergizes with SRC inhibition, providing a new opportunity for enhancing the clinical effectiveness of SRC inhibitors in breast cancer." 01/01/2022 - "Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors." 09/01/2018 - "Expression of EMT inducers integrin-linked kinase (ILK) and ZEB1 in phyllodes breast tumors is associated with aggressive phenotype." 04/01/2016 - "Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer." 01/01/2016 - "Here we report that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells (CSC) through modulation of the integrin-linked kinase ILK. "
5.	Squamous Cell Carcinoma of Head and Neck 08/01/2017 - "To investigate the expression of integrin-linked kinase (ILK) and its relationship with clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC). " 08/01/2017 - "Clinical significance of integrin-linked kinase in laryngeal squamous cell carcinoma." 10/01/2010 - "To investigate the expression patterns of integrin-linked kinase (ILK) in oral squamous cell carcinoma (OSCC). " 12/01/2018 - "Integrin-linked kinase is overexpressed in laryngeal squamous cell carcinoma and correlates with tumor proliferation, migration and invasion." 12/01/2017 - "Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma."

Related Drugs and Biologics

1.	QLT 0267
2.	Protein Kinases (Protein Kinase)
3.	Phosphotransferases (Kinase)
4.	Aurora Kinases
5.	Peroxisome Proliferator-Activated Receptors (PPAR)
6.	AMPA Receptors (AMPA Receptor)
7.	Actins (F Actin)
8.	Docetaxel (Taxotere)
9.	Integrins
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics
3.	Microbubbles
4.	Moxibustion
5.	Drug Therapy (Chemotherapy)