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integrin-linked kinase

Subscribe to New Research on integrin-linked kinase

regulates cell adhesion and anchorage-dependent growth; MW 59 kDa; ILK-2 is an isoform

Also Known As:

ILK protein, human; ILK-2 kinase; Ilk protein, mouse; Ilk protein, rat; integrin linked kinase, mouse; integrin linked kinase, rat; integrin-linked kinase, human; integrin-linked kinase-2; p59 ILK; p59(ILK)

Networked: 286 relevant articles (4 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        integrin-linked kinase: 286

Experts

1.	Dedhar, Shoukat: 34 articles (03/2014 - 03/2003)
2.	Wu, Chuanyue: 13 articles (02/2013 - 08/2002)
3.	Li, Gang: 8 articles (03/2015 - 10/2003)
4.	Dedhar, S: 8 articles (02/2011 - 03/2000)
5.	Hannigan, Gregory: 7 articles (01/2013 - 01/2005)
6.	Bally, Marcel B: 6 articles (09/2015 - 05/2005)
7.	Assi, Kiran: 6 articles (01/2014 - 11/2007)
8.	Chen, Ching-Shih: 5 articles (01/2016 - 09/2011)
9.	Mills, Julia: 5 articles (01/2015 - 12/2003)
10.	Xu, Biao: 5 articles (12/2014 - 09/2009)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2013 - "Recent studies have also shown that the down-regulation of integrin-linked kinase has anti-tumor potential by inhibiting the metastatic potential of several types of cultured human cancer cells. " 09/01/2015 - "Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model of Cancer." 07/01/2015 - "The expression of integrin-linked kinase (ILK) has been reported to be involved in the regulation of integrin-mediated processes, including cancer cell proliferation, migration and invasion. " 01/01/2015 - "Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines." 03/01/2014 - "LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase."
2.	Breast Neoplasms (Breast Cancer) 12/25/2015 - "Parvin-β is an adaptor protein that binds to integrin-linked kinase (ILK) and is significantly downregulated in breast tumors and breast cancer cell lines. " 01/01/2010 - "Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development." 09/01/2008 - "Furthermore, integrin-linked kinase can 'convert' localized breast cancer cells into invasive and metastatic cells. " 11/25/2004 - "We analysed breast tumors and breast cancer cell lines for the expression of beta-parvin (ParvB), an adaptor protein that binds to the integrin-linked kinase (ILK). " 11/25/2004 - "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer."
3.	Proteinuria 08/01/2010 - "Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria." 05/01/2006 - "Integrin-linked kinase (ILK) has been implicated in podocyte cell-matrix interaction and is induced in proteinuria. " 08/01/2001 - "Integrin-linked kinase as a candidate downstream effector in proteinuria." 08/01/2006 - "Integrin-linked kinase (ILK) has been implicated in the pathogenesis of proteinuria and congenital nephrotic syndrome. " 08/01/2010 - "Since binding of these cells to the basement membrane is mediated by integrins, we determined the role of integrin-linked kinase (ILK) in podocyte dysfunction and proteinuria. "
4.	Acute Liver Failure (Fulminant Hepatic Failure) 01/01/2011 - "Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice."
5.	Carcinoma (Carcinomatosis) 02/01/2013 - "The objective of this study is to analyze the expression and clinical role of integrin-linked kinase (ILK), α-parvin, β-parvin and migfilin in advanced-stage serous ovarian carcinoma. " 04/01/2012 - "Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma." 01/01/2012 - "Role of integrin-linked kinase in multi-drug resistance of human gastric carcinoma SGC7901/DDP cells." 01/01/2009 - "Fish oil inhibits human lung carcinoma cell growth by suppressing integrin-linked kinase." 11/01/2008 - "Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas."

Related Drugs and Biologics

1.	QLT 0267
2.	squamous cell of head and neck Carcinoma
3.	Actins (F Actin)
4.	docetaxel (Taxotere)
5.	Cadherins (E-Cadherin)
6.	Protein Kinases (Protein Kinase)
7.	Focal Adhesion Protein-Tyrosine Kinases
8.	Integrins
9.	Messenger RNA (mRNA)
10.	beta Catenin

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Microbubbles
4.	Homologous Transplantation (Allograft)