4- iodine- benzo(b)thiophene- 2- carboxamidine (B 428)

05/01/2000 - "In this study using Matrigel invasion chambers and two separate uPA inhibitors, amiloride and B428, the invasive capacity of unaltered human breast cancer cells was significantly suppressed. "
05/01/2000 - "Suppression of the invasive capacity of human breast cancer cells by inhibition of urokinase plasminogen activator via amiloride and B428."
08/15/1997 - "Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428."

05/01/2003 - "Moreover, the catalytic inhibition of uPA by a synthetic uPA inhibitor B428 reduced local tumor invasiveness but not tumor cell dissemination. "
08/15/1997 - "In contrast to this, experimental animals receiving TAM and B-428 showed a significant decrease in primary tumor volume and metastases. "
12/11/1995 - "The occasional tumor metastases observed after infusion of B-428 were significantly smaller than those observed in vehicle controls. "
11/01/1998 - "B428 exerted a dose-dependent inhibition of Matrigel invasion by F3II cells and also reduced tumor cell adhesion and migration using the same doses. "
11/01/1998 - "Inhibition of mammary tumor cell adhesion, migration, and invasion by the selective synthetic urokinase inhibitor B428."

05/01/2003 - "We evaluated the effect of a combined treatment with verapamil and B428 on the murine mammary carcinoma F3II behavior in vivo and in vitro. "
11/01/1998 - "We have analyzed the anti-invasive properties of the selective synthetic urokinase inhibitor 4-iodo benzo[b]thiopene-2-carboxamidine (B428) in the mouse mammary carcinoma model F3II. "
01/01/1996 - "We have evaluated the antiinvasive and antimetastatic properties of two recently developed synthetic uPA inhibitors, B428 and B623, in a BALB/c mouse mammary carcinoma model. "
05/01/2003 - "Combined treatment with verapamil, a calcium channel blocker, and B428, a synthetic uPA inhibitor, impairs the metastatic ability of a murine mammary carcinoma."

08/15/1997 - "In contrast to this, experimental animals receiving TAM and B-428 showed a significant decrease in primary tumor volume and metastases. "
12/11/1995 - "The occasional tumor metastases observed after infusion of B-428 were significantly smaller than those observed in vehicle controls. "
08/15/1997 - "Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428."

02/01/2006 - "Matrigel invasion assays with two specific uPA inhibitors, B428 and p-aminobenzamidine, showed that invasion of a prostate cancer cell line containing uPA gene amplification was inhibited by these small-molecule uPA inhibitors, while invasion of prostate cell lines without uPA gene amplification were not. "