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polymannose

RN given for D-isomer

Also Known As:

mannose homopolymer; poly(mannose)

Networked: 14 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Mannans: 580
    - polymannose: 14

Experts

1.	Konefal, Janet: 3 articles (01/2020 - 01/2013)
2.	Lewis, John E: 3 articles (01/2020 - 01/2013)
3.	McDaniel, H Reginald: 3 articles (01/2020 - 01/2013)
4.	Woolger, Judi M: 3 articles (01/2020 - 01/2013)
5.	Martin, Alicia: 2 articles (01/2020 - 01/2018)
6.	Miguez, Maria-Jose: 2 articles (01/2020 - 01/2018)
7.	Stillman, Jordan: 2 articles (01/2020 - 01/2018)
8.	Androutsou, Maria-Eleni: 1 article (10/2020)
9.	Avloniti, Maria: 1 article (10/2020)
10.	Dagkonaki, Anastasia: 1 article (10/2020)

Related Diseases

1.	Dementia (Dementias) 01/29/2020 - "The objective of the present study was to investigate the relationships among pro-brain-derived neurotrophic factor (BDNF) and mature BDNF and immune functioning during aloe polymannose multinutrient complex (APMC) treatment in persons with moderate to severe Alzheimer's dementia (AD). " 01/15/2018 - "The objective of the present study was to investigate the effect of an aloe polymannose multinutrient complex (APMC) on pro brain-derived neurotrophic factor (BDNF) and mature BDNF in persons with moderate to severe Alzheimer's dementia. "
2.	Lymphoma (Lymphomas) 07/01/2000 - "Employing as a model system castanospermine-treated BW5147 mouse T-lymphoma cells in which accelerated degradation of the T-cell receptor (TCR) alpha subunit takes place (Kearse et al. (1994) EMBO J., 13, 3678-3686), we noted that both lactacystin and N-acetyl-L-leucyl-L-leucyl-L-norleucinal, but not leupeptin, brought about a rapid and substantial reduction in the release of free polymannose oligosaccharides into the cytosol during pulse-chase studies, while the oligosaccharides in the intravesicular compartment remained unchanged, as measured by streptolysin O permeabilization. "
3.	Anaphylaxis (Anaphylactic Shock) 01/01/2001 - "In this study, LPS specimens carrying mannose-homopolymer (MHP), which markedly activate the human complement system through the lectin pathway, induced marked platelet degradation and anaphylactoid shock in BALB/c mice. " 01/01/2001 - "Complement-dependent platelet degradation and anaphylactoid shock in mice induced by lipopolysaccharide carrying the mannose homopolymer."
4.	Neoplasms (Cancer) 11/01/2019 - "As mannose receptors are known to be over-expressed in cancer cells, we synthesized polymannose-doxorubicin (PM-DOX) conjugates with the objective of targeting the drug to cancer cells. " 02/01/1999 - "Mucins (MUC1) have attracted interest as potential targets for immunotherapy of cancers of breast, pancreas, ovary and others, and we have demonstrated that mannan, a polymannose carbohydrate is an effective carrier for MUC1 in eliciting a cellular immune response. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/13/1997 - "Transfer of free polymannose-type oligosaccharides from the cytosol to lysosomes in cultured human hepatocellular carcinoma HepG2 cells." 05/07/1999 - "In hepatocellular carcinoma HepG2 cells, free polymannose-type oligosaccharides appearing in the cytosol during the biosynthesis and quality control of glycoproteins are rapidly translocated into lysosomes by an as yet poorly defined process (Saint-Pol, A., Bauvy, C., Codogno, P., and Moore, S. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Oligosaccharides
3.	Lectins
4.	T-Cell Antigen Receptors (T-Cell Receptor)
5.	Complement System Proteins (Complement)
6.	lactacystin
7.	castanospermine
8.	leupeptin
9.	streptolysin O
10.	Mannans

Related Therapies and Procedures

1.	Immunotherapy