SDZ 217766

structure in first source

Also Known As:

Boc-D-TMSal-Pro-boroArg-OPin; N-((1,1-dimethylethoxy)carbonyl)-trimethylsilylalanyl-N-(4-guanidino-1-(hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl)butyl)prolinamide; SDZ 217,766; SDZ 217-766; SDZ-217-766; SDZ-217766

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - SDZ 217766: 1
Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - SDZ 217766: 1

Related Diseases

1.	Venous Thrombosis (Deep-Vein Thrombosis) 04/01/1995 - "In the venous thrombosis model, SDZ 217-766 infused at 10 micrograms/kg/min and 20 micrograms/kg/min, reduced thrombus formation by 35% and 70%, respectively. " 04/01/1995 - "Antithrombotic potency of SDZ 217-766, a potent inhibitor of thrombin and other trypsin-like serine proteases, was studied in comparison with heparin in rat models of thrombin induced lung platelet accumulation, of thrombosis in arterio-venous shunt, and of venous thrombosis induced by tissue factor. "
2.	Thrombosis (Thrombus) 04/01/1995 - "In the same model, heparin administered either i.v., 30-300 IU/kg, or subcutaneously, 100 and 300 IU/kg, inhibited thrombus formation dose dependently but in contrast to SDZ 217-766, the inhibitory effect was paralleled by 5-to > 10 fold APTT elevation over baseline. " 04/01/1995 - "In the venous thrombosis model, SDZ 217-766 infused at 10 micrograms/kg/min and 20 micrograms/kg/min, reduced thrombus formation by 35% and 70%, respectively. " 04/01/1995 - "Thrombin-induced platelet accumulation in the lung was inhibited dose-dependently by SDZ 217-766 following intravenous (i.v.) administration of 0.03 mg/kg to 0.3 mg/kg as well as by intraduodenal (i.d.) administration of 3 mg/kg and 10 mg/kg. Comparable inhibitory effects were observed with heparin at 30 IU/kg and 100 IU/kg. In the rat arterio-venous shunt, following i.v. administration of SDZ 217-766, thrombus formation was inhibited by 40% at 0.1 mg/kg, by 60% at 0.3 mg/kg and was abolished at 1.0 mg/kg whilst APTT was prolonged 1.1 fold over the control value at 0.1 mg/kg and 2.7 fold at 1.0 mg/kg. Similar inhibitory effects were observed following i.d. " 04/01/1995 - "Antithrombotic potency of SDZ 217-766, a potent inhibitor of thrombin and other trypsin-like serine proteases, was studied in comparison with heparin in rat models of thrombin induced lung platelet accumulation, of thrombosis in arterio-venous shunt, and of venous thrombosis induced by tissue factor. "

Related Drugs and Biologics

1.	Serine Proteases (Serine Protease)
2.	Trypsin
3.	Thromboplastin (Tissue Factor)
4.	Thrombin
5.	Heparin (Liquaemin)
6.	Dihydrotachysterol (AT 10)