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tenofovir

Also Known As:

(R)-9-(2-phosphonylmethoxypropyl)adenine; 9-(2-phosphonomethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine, (+-)-isomer; 9-(2-phosphonylmethoxypropyl)adenine, (R)-isomer; 9-(2-phosphonylmethoxypropyl)adenine, (S)-isomer; 9-PMPA

Networked: 962 relevant articles (119 outcomes, 154 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Abdool Karim, Salim S: 14 articles (11/2015 - 09/2010)
2.	De Clercq, Erik: 13 articles (11/2013 - 10/2003)
3.	Oka, Shinichi: 12 articles (06/2015 - 01/2011)
4.	Abdool Karim, Quarraisha: 11 articles (11/2015 - 09/2010)
5.	Van Rompay, Koen K A: 11 articles (01/2012 - 11/2002)
6.	Girard, Pierre-Marie: 10 articles (11/2015 - 12/2002)
7.	Baxter, Cheryl: 10 articles (08/2015 - 09/2010)
8.	Gatanaga, Hiroyuki: 10 articles (12/2014 - 01/2011)
9.	Bischofberger, Norbert: 10 articles (09/2008 - 11/2002)
10.	Sax, Paul E: 9 articles (06/2015 - 03/2009)

Related Diseases

1.	Infection 01/01/2010 - "Tenofovir was effective against HIV-1 infection in our algorithm. " 12/01/2005 - "Tenofovir is effective in treating HBV infection in HIV patients. " 04/28/2003 - "Tenofovir effective in all stages of the infection]." 02/09/2013 - "In patients with chronic HBV infection, up to 5 years of treatment with tenofovir DF was safe and effective. " 09/01/2014 - "To evaluate the safety and efficacy of the novel tenofovir prodrug, tenofovir alafenamide (TAF), as part of a single-tablet regimen (STR) for the initial treatment of HIV-1 infection. "
2.	Chronic Hepatitis B 06/01/2015 - "In conclusion, the tenofovir rescue regimen can be employed confidently as a highly effective and safe treatment choice following a suboptimal response to ETV plus ADV therapy for a subset of chronic hepatitis B patients with a history of multiple unsuccessful antiviral treatments." 12/01/2012 - "This study evaluated the safety and efficacy of tenofovir DF in adolescents with chronic hepatitis B (CHB). " 06/01/2015 - "Efficacy of tenofovir switch therapy for nucleos(t)ide-experienced patients with chronic hepatitis B." 01/01/2015 - "[Efficacy of tenofovir-based rescue therapy for patients with drug-resistant chronic hepatitis B]." 09/01/2013 - "Safety of coitally administered tenofovir 1% gel, a vaginal microbicide, in chronic hepatitis B virus carriers: results from the CAPRISA 004 trial."
3.	HIV Infections (HIV Infection) 03/01/2012 - "Topical tenofovir gel has proven effective in the prevention of HIV infection in women in South Africa. " 07/01/2013 - "Tenofovir (TFV) is a widely used and effective treatment for HIV infection. " 01/01/2012 - "Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We" 07/01/2015 - "Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness." 04/24/2015 - "In this HIV PrEP trial among people who inject drugs, improved adherence to daily tenofovir was associated with a lower risk of HIV infection. "
4.	Hepatitis B 07/01/2015 - "First report of successful clearance of hepatitis B and D coinfection with tenofovir monotherapy." 01/01/2009 - "New approaches in the management of chronic hepatitis B: role of tenofovir." 12/01/2015 - "Tenofovir, an agent used in HIV and hepatitis B therapy, may also have a role in the prevention of HSV-2 acquisition and reduce viral shedding. " 03/01/2015 - "Tenofovir alafenamide 25 mg has been selected for further hepatitis B clinical development." 05/01/2014 - "Factors associated with delayed hepatitis B viral suppression on tenofovir among patients coinfected with HBV-HIV in the CNICS cohort."
5.	Fibrosis (Cirrhosis) 01/01/2007 - "The safety and efficacy of tenofovir in HIV/HBV cirrhosis has not been previously described. " 02/01/2015 - "One patient with compensated cirrhosis needed to change from tenofovir because of renal safety. " 11/01/2013 - "We aimed to evaluate the usefulness of various prognostic indicators in predicting the 24-months survival in HBV related decompensated cirrhosis after tenofovir therapy and to evaluate the post-treatment outcome. " 11/01/2013 - "Predictors of survival in hepatitis B virus related decompensated cirrhosis on tenofovir therapy: an Indian perspective." 09/01/2013 - "Virological response was better in patients using tenofovir (Odd's ratio of 1.796 and p = 0.014) and having high fibrosis score (Odd's ratio of 0.182 and p = 0.018). "

Related Drugs and Biologics

1.	entecavir
2.	emtricitabine (Emtriva)
3.	Lamivudine (3TC)
4.	adefovir
5.	pinacolyl methylphosphonic acid
6.	efavirenz (Sustiva)
7.	Hepatitis B e Antigens
8.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
9.	Ritonavir (Norvir)
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Liver Transplantation
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Injections
4.	Contraception (Birth Control)
5.	Transplantation (Transplant Recipients)