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KR 30450
activates the cardiac ATP-sensitive potassium channel; structure in first source
Also Known As:
2-(1'',3''-dioxolan-2''-yl)-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro-2H-1-benzopyran; KR-30450; SKP-450; 2-Pyrrolidinone, 1-(2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-1-benzopyran-4-yl)-, (R)-
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
KR 30450: 5
Pyrrolidines: 115
Pyrrolidinones: 162
KR 30450: 5
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
KR 30450: 5
Related Diseases
1.
Ulcer
09/01/1999 - "
A significant reduction in the ulcer index by SKP-450 was also observed in 0.3 n NaOH-treated rats (31.5 and 64.3% inhibition at 0.5 and 1.0 mg kg(-1), respectively).
"
09/01/1999 - "
These results indicate that SKP-450 possesses anti-ulcer effects and its effects may be mediated by activation of ATP-sensitive potassium channels.
"
09/01/1999 - "
Anti-ulcer activity of SKP-450, a novel potassium channel activator, in rats.
"
09/01/1999 - "
The anti-ulcer effects of SKP-450, a new potassium channel activator, were evaluated on basal and histamine-induced gastric acid secretion, and against experimentally-induced ulcers such as ethanol-induced and NaOH-induced gastric ulcers.
"
09/01/1999 - "
The effects of SKP-450 on histamine-induced acid secretion and on NaOH-induced ulcers were inhibited by glibenclamide (20 mg kg(-1), i.v.), a selective blocker of ATP-sensitive potassium channel.
"
2.
Tachycardia (Tachyarrhythmias)
01/01/1998 - "
In conscious dogs, orally administered SKP-450 (0.03-0.3 mg/kg) produced a dose-related decrease in arterial pressure for > or =3 h, with its peak effects reached within 20 min (ED20 value, 0.030 mg/kg) accompanied by tachycardia.
"
03/01/1998 - "
Glybenclamide antagonized all the hemodynamic effects of SKP-450 in rats and dogs, whereas propranolol antagonized its reflex tachycardia in rats.
"
03/01/1998 - "
In rats, SKP-450, SKP-818 and lemakalim (3-100 micrograms/kg, i.v.) induced a dose-dependent decrease in mean arterial pressure (MAP; ED20: 9.8, 11.7 and 22.4 micrograms/kg, respectively) followed by reflex tachycardia.
"
3.
Wounds and Injuries (Trauma)
11/03/1999 - "
The increased [3H]thymidine incorporation and migration (chemotactic and wound-edge) of the cultured smooth muscle cells in association with increased production of platelet-derived growth factor (PDGF)-BB-like immunoreactivity stimulated by oxidized LDL were significantly reduced by SKP-450 (10(-7)-10(-6) M).
"
4.
Stomach Ulcer (Gastric Ulcer)
09/01/1999 - "
The anti-ulcer effects of SKP-450, a new potassium channel activator, were evaluated on basal and histamine-induced gastric acid secretion, and against experimentally-induced ulcers such as ethanol-induced and NaOH-induced gastric ulcers.
"
5.
Contracture
01/01/1998 - "
KR-30450 and KR-30818 significantly attenuated reperfusion contracture and lactate dehydrogenase release with potency greater than and equal to lemakalim, respectively.
"
Related Drugs and Biologics
1.
Cromakalim (Levcromakalim)
2.
Glyburide (Glibenclamide)
3.
KATP Channels
4.
Potassium Channels (Potassium Channel)
5.
Thymidine
6.
Propranolol (Inderal)
7.
Platelet-Derived Growth Factor
8.
L-Lactate Dehydrogenase (Lactate Dehydrogenase)
9.
Histamine (Histamine Dihydrochloride)
10.
Ethanol (Ethyl Alcohol)