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7-aminocephalosporin doxorubicin-poly(ethylene glycol)propionic acid N-hydroxysuccinimide ester

structure in first source

Also Known As:

B-PEG-AC-Dox

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - beta-Lactams: 2386
      - Cephalosporins: 4007
        7-aminocephalosporin doxorubicin-poly(ethylene glycol)propionic acid N-hydroxysuccinimide ester: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        7-aminocephalosporin doxorubicin-poly(ethylene glycol)propionic acid N-hydroxysuccinimide ester: 1
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        7-aminocephalosporin doxorubicin-poly(ethylene glycol)propionic acid N-hydroxysuccinimide ester: 1

Related Diseases

1.	Neoplasms (Cancer) 07/01/1995 - "B-PEG-AC-Dox cleared from the blood more slowly than M-PEG-AC-Dox and was retained to a 2.1-fold greater extent in human 3677 melanoma tumor xenografts over a 4 h period. "
2.	Melanoma (Melanoma, Malignant) 07/01/1995 - "B-PEG-AC-Dox cleared from the blood more slowly than M-PEG-AC-Dox and was retained to a 2.1-fold greater extent in human 3677 melanoma tumor xenografts over a 4 h period. "
3.	Adenocarcinoma of Lung 07/01/1995 - "Both M-PEG-AC-Dox (IC50 = 80 microM) and B-PEG-AC-Dox (IC50 = 8 microM) were less toxic to H2981 human lung adenocarcinoma cells than doxorubicin (IC50 = 0.1-0.2 microM) and could be activated in an immunologically specific manner by L6-bL, a monoclonal antibody-bL conjugate that bound to H2981 cell surface antigens. "

Related Drugs and Biologics

1.	7-aminocephalosporin doxorubicin-monomethoxypoly(ethylene glycol)propionic acid N-hydroxysuccinimide ester
2.	Doxorubicin (Adriamycin)
3.	Surface Antigens (Surface Antigen)
4.	Monoclonal Antibodies