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benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

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an interleukin-1beta converting enzyme (ICE)-like protease inhibitor

Also Known As:

Ac-DEVD-CMK; Ac-ZVAD-FMK; FK 009; FK-009; FK009; Z-VAD-FMK; Z-VAD.FMK; Z-Val-Ala-Asp-fluoromethylketone; ZVAD-FMK; ZVAD-fluoromethylketone; carbobenzoxyvalyl-alanyl-aspartyl fluoromethyl ketone

Networked: 257 relevant articles (9 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Amino Acids: 10808
  - Amino Acid Chloromethyl Ketones
    - benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: 257

Experts

1.	Rossi, Adriano G: 3 articles (01/2011 - 09/2006)
2.	Onodera, Satoshi: 2 articles (11/2013 - 12/2005)
3.	Ikejima, Takashi: 2 articles (11/2013 - 12/2005)
4.	Tashiro, Shin-Ichi: 2 articles (11/2013 - 12/2005)
5.	Engel, Jörg B: 2 articles (03/2011 - 08/2009)
6.	Dietl, Johannes: 2 articles (03/2011 - 08/2009)
7.	Krockenberger, Mathias: 2 articles (03/2011 - 08/2009)
8.	Honig, Arnd: 2 articles (03/2011 - 08/2009)
9.	Schönhals, Tanja: 2 articles (03/2011 - 08/2009)
10.	Wischhusen, Jörg: 2 articles (03/2011 - 08/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "PQQ induced tumor cells apoptosis was significantly alleviated by pan-caspase inhibitor Z-VAD-FMK. " 11/15/2010 - "Z-VAD-FMK, a pan-caspase inhibitor, partially prevented CPX-induced cell death, suggesting that CPX-induced apoptosis of cancer cells is mediated at least in part through caspase-dependent mechanism. " 12/01/2009 - "Furthermore, NK cell death after internalization is attenuated by the caspase inhibitor, Z-VAD-FMK, confirming apoptosis as the mode of NK cell death within tumor cells. " 08/01/2009 - "Live cell imaging showed that the function-blocking mechanism of mAb 41-2 involved enhancement of tumor cell apoptosis, confirmed by attenuation of mAb 41-2-mediated effects with the caspase inhibitor z-VAD-fmk. " 04/01/2009 - "Pretreatment of the cells with the pan-caspase inhibitor z-VAD-fmk abolished the cleavage of PARP by AH-Me treatment and suppressed the antiproliferative effect of AH-Me on tumor cell growth. "
2.	Necrosis 11/15/2001 - "Electron microscopic observations demonstrated that z-VAD-fmk suppressed nuclear fragmentation and improved mitochondrial swelling, but failed to prevent vesicular formation, which resulted in a slowly-occurring necrosis. " 10/01/2015 - "We investigated the effects of the caspase inhibitor z-VAD-fmk, which inhibits apoptosis but promotes death domain receptor (DR)-induced NPC cell necrosis. " 01/01/2015 - "However, comparing the TNFα-induced cell death in these two cell lines, we found that, unlike the L929-N cells that show typical RIP3-dependent necrosis, TNFα-induced cell death in L929-A cells is pan-caspase inhibitor Z-VAD-FMK (Z-VAD)-sensitive, which does not depend on RIP3. " 12/01/2014 - "Then, the autophagy inhibitor (3-methyladenine), caspase inhibitor (Z-VAD-FMK) or necrosis inhibitor (necrostatin) was used to prevent death. " 08/01/2014 - "However, pretreatment with Necrox-2 or Necrox-5, two novel necrosis inhibitors, suppressed cell death more markedly compared with pretreatment with zVAD-fmk. "
3.	Ischemia 02/01/2010 - "The preadministration of a pan-caspase inhibitor, zVAD-fmk, prevented phosphatidylserine exposure after ischemia. " 08/18/2000 - "Hearts were made ischemic for 45 min and reperfused for 180 min. Under these conditions, it was determined that zVAD.fmk was cardioprotective when administered before or after the onset of ischemia, whereas BocD.fmk was efficacious only when administered before the onset of ischemia. " 07/01/2004 - "Before and after ischemia, daily injections of z-VAD-fmk or vehicle were administered into the lateral cerebral ventricle for 14 days. " 08/18/2000 - "The aim of this study was to determine the effect of different administration protocols on the cardioprotective efficacy of the non-selective, irreversible caspase inhibitors N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVAD.fmk) and bocaspartyl-(OMe)-fluoromethylketone (BocD.fmk) in a rat in vivo ischemia and reperfusion paradigm. " 09/01/2003 - "Group D consisted of animals subjected to experimental ischemia and to a dose of the caspase inhibitors z-VAD.FMK and z-DEVD.FMK injected intracerebroventricularly through the right hemisphere before the surgical procedure. "
4.	Cachexia 04/01/2015 - "Combined treatment with CFZ and z-VAD-fmk early in the development of cachexia was associated with signs of less proteolysis and apoptosis and less severe cachexia in a mouse model of cancer-induced cachexia. " 04/01/2015 - "Combined treatment of carfilzomib and z-VAD-fmk inhibits skeletal proteolysis and apoptosis and ameliorates cancer cachexia." 04/01/2015 - "The purpose of the study was to evaluate the therapeutic benefit of treatments with carfilzomib (CFZ) and z-VAD-fmk in a mouse model of cancer-induced cachexia. "
5.	Melanoma (Melanoma, Malignant) 01/01/2015 - "Supernatants (SNs) of melanoma cells whose cell death was modulated with zVAD-fmk induced an upregulation of the activation markers CD86 and MHCII on macrophages. " 03/01/2007 - "These results were supported by the use of the pan-caspases inhibitor Z-VAD-FMK that almost completely decreased the amount of apoptosis in both the melanoma cell lines treated with antifolate. " 01/01/2015 - "Necroptosis was inducible in poorly immunogenic B16-F10 melanoma cells and zVAD-fmk generally increased melanoma cell necrosis concomitantly with the release of HMGB1. " 05/01/2013 - "This article shows that parthenolide stimulates in human osteosarcoma MG63 and melanoma SK-MEL-28 cells a mechanism of cell death, which is not prevented by z-VAD-fmk and other caspase inhibitors. " 01/01/2015 - "We conclude that HMGB1, nucleotides and CD8+ T cells mediate zVAD-fmk induced anti-melanoma immune reactions in multimodal therapy settings. "

Related Drugs and Biologics

1.	alanylaspartic acid
2.	Caspase 3 (Caspase-3)
3.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone
4.	carfilzomib
5.	DNA (Deoxyribonucleic Acid)
6.	Sepharose (Agarose)
7.	Dacarbazine (DIC)
8.	bafilomycin A1
9.	Caspases
10.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

Related Therapies and Procedures

1.	Laminectomy
2.	Injections
3.	Transplantation (Transplant Recipients)
4.	Ligation
5.	Hepatectomy