HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

L 709049

a reversible interleukin-1beta-converting enzyme inhibitor

Also Known As:

Ac-Tyr-Val-Ala-Asp-CHO; Ac-YVAD-cho; L 709,049; L-709,049; L-709049; N-acetyltyrosyl-valyl-alanyl-aspartyl aldehyde; YCAD-CHO; acetyl-Tyr-Val-Ala-Asp-CHO; acetyl-tyrosyl-valyl-alanyl-aspartinal

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 22950
  - Oligopeptides: 168
    - L 709049: 4

Experts

1.	Li, Sheng-An: 1 article (01/2013)
2.	Gao, Qian: 1 article (01/2013)
3.	Yan, Chao: 1 article (01/2013)
4.	Liu, Jie: 1 article (01/2013)
5.	Wang, Xuan: 1 article (01/2013)
6.	Xiang, Yang: 1 article (01/2013)
7.	Zhang, Yun: 1 article (01/2013)
8.	Zhou, Kaifeng: 1 article (01/2013)
9.	Guo, Xiaolong: 1 article (01/2013)
10.	Lee, Wenhui: 1 article (01/2013)

Related Diseases

1.	Reperfusion Injury 10/01/1999 - "To study the roles of the caspases in retinal ischemia-reperfusion injury, an inhibitor of caspase-1, acetyl-tyrosyl-valyl-alanyl-aspart-1-al (Ac-YVAD-CHO; total dose, 10(-7) moles) and that of caspase-3, acetyl-aspartyl-glutamylvalyl-aspart-1-al (Ac-DEVD-CHO; total dose, 10(-7) moles) was injected intravitreally and the number of TUNEL-positive cells was compared with the number in sections not treated with the inhibitors. "
2.	Melanoma (Melanoma, Malignant) 01/01/2001 - "Melanoma cell apoptosis induced by iNOS inhibition was completely blocked by peptide inhibitors of caspase-1 and caspase-3 (Ac-DEVD-CHO and AC-YVAD-CHO) or by an exogenous NO donor, sodium nitroprusside, or by addition of serum. "
3.	Escherichia coli Infections 12/01/2002 - "cas-1(-/-) and Cas-1 inhibitor (Ac-YVAD-CHO)-treated cas-1(+/+) mice were two- to threefold more susceptible to lethal Escherichia coli infection than cas-1(+/+) mice. "
4.	Bacterial Infections (Bacterial Infection) 01/01/2013 - "Ac-YVAD-cho also significantly attenuated the protective effect of ATP against bacterial infection. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	acetyl-aspartyl-glutamyl-valyl-aspartal
3.	Caspases
4.	Retinaldehyde (Retinal)
5.	Nitroprusside (Sodium Nitroprusside)
6.	Adenosine Triphosphate (ATP)