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DNA- (2- amino- 3- methylimidazo(4,5- f)quinoline) adduct

Also Known As:

2-AMIQ-DNA adduct; IQ-DNA adduct

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - DNA: 145982
    - DNA Adducts: 2237
      - DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct: 4
Genetic Phenomena
- DNA Damage
  - DNA Adducts: 2237
    - DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct: 4

Related Diseases

1.	Neoplasms (Cancer) 02/01/1994 - "The finding of high cardiac IQ-DNA adduct levels prompted a histopathological study of perfusion-fixed hearts from 10 tumor-bearing monkeys chronically dosed with IQ at 10 mg/kg or 20 mg/kg 5 days per week for 48-80 months. " 05/12/1997 - "It is concluded that (1) the rate of PhIP- and IQ-DNA adduct removal depends on the dose and frequency of administration, (2) urinary PhIP may be a good biomarker of recent PhIP exposure and (3) CLA, I3C and IPO are potential chemopreventive agents against PhIP- or IQ-induced tumors in rodents."
2.	Carcinogenesis 08/01/1997 - "MO may affect the initiation phase of IQ tumorigenesis by inhibiting IQ-DNA adduct formation in certain target organs." 09/01/1993 - "While dietary MO is generally thought to inhibit experimental tumorigenesis at the promotional stage, the present results show that MO diets may also inhibit the initiation process by inhibiting the initial rate of IQ-DNA adduct formation. " 08/01/1997 - "Because DNA adduct formation is considered to be a critical event in the initiation of carcinogenesis, we have assessed the effects of dietary MO on IQ-DNA adduct formation. "

Related Drugs and Biologics

1.	Dihydrotachysterol (AT 10)
2.	DNA Adducts
3.	Biomarkers (Surrogate Marker)
4.	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridine