nascent-polypeptide-associated complex

a heterodimer; involved in the regulation of the association of signal recognition particle with nascent chains; a ribosome-binding preventing factor

Also Known As:

NACA protein, human; Naca protein, mouse; alpha-NAC protein; nascent polypeptide-associated complex alpha polypeptide, mouse; nascent polypeptide-associated complex and coactivator alpha protein; nascent-polypeptide-associated complex alpha polypeptide; nascent-polypeptide-associated complex alpha polypeptide, human; skNAC protein, mouse

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Molecular Chaperones: 1279
    - nascent-polypeptide-associated complex: 7

Experts

1.	Mittermann, Irene: 2 articles (06/2008 - 10/2002)
2.	Reininger, Renate: 2 articles (06/2008 - 10/2002)
3.	Spitzauer, Susanne: 2 articles (06/2008 - 10/2002)
4.	Valenta, Rudolf: 2 articles (06/2008 - 10/2002)
5.	Hotokezaka, Y: 1 article (04/2015)
6.	Katayama, I: 1 article (04/2015)
7.	Nakamura, T: 1 article (04/2015)
8.	van Leyen, K: 1 article (04/2015)
9.	Chen, X: 1 article (06/2014)
10.	Peng, C: 1 article (06/2014)

Related Diseases

1.	Neoplasms (Cancer) 06/05/2014 - "Nascent polypeptide-associated complex α (αNAC) is reportedly overexpressed in several types of cancers and regulates cell apoptosis under hypoxic conditions in HeLa cells. " 04/01/1997 - "Those matched known genes included genes for parathyroid tumor, T cell receptor-beta, alpha-nascent polypeptide-associated complex, ovarian cancer, and myeloblast. "
2.	Atopic Dermatitis (Atopic Eczema) 10/01/2002 - "Furthermore, recombinant alpha-nascent polypeptide-associated complex induced specific lymphoproliferative responses in peripheral blood mononuclear cells of a sensitized atopic dermatitis patient. " 10/01/2002 - "Recently, we provided evidence that a component of nascent polypeptide-associated complex, alpha-nascent polypeptide-associated complex, represents an IgE-reactive autoantigen for atopic dermatitis patients. " 06/01/2008 - "Hom s 2, the alpha-chain of the nascent polypeptide-associated complex, is an intracellular autoantigen that has been identified with IgE autoantibodies from atopic dermatitis patients. "
3.	Ovarian Neoplasms (Ovarian Cancer) 04/01/1997 - "Those matched known genes included genes for parathyroid tumor, T cell receptor-beta, alpha-nascent polypeptide-associated complex, ovarian cancer, and myeloblast. "
4.	Inflammation (Inflammations) 11/01/2008 - "Recent findings in experimental animals support the involvement of an autoreactive mechanism in allergic asthma as well, indicating that human alpha-nascent polypeptide-associated complex, identified as an IgE-reactive autoantigen, has the potential to sensitize and induce immediate skin reactions and airway inflammation. "
5.	Down Syndrome (Down's Syndrome) 07/01/2002 - "Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome."

Related Drugs and Biologics

1.	Immunoglobulin E (IgE)
2.	Autoantigens
3.	T-Cell Antigen Receptors (T-Cell Receptor)
4.	Glycogen Synthase (Synthase I)
5.	Autoantibodies