chymotrypsinogen C

a single-chain zymogen of 251 residues; a precursor of a chymotrypsin-like serine endopeptidase that cleaves preferentially after aliphatic residues, releasing peptides that are substrates of carboxypeptidase A; has been sequenced

Networked: 12 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sahin-Tóth, Miklós: 3 articles (01/2019 - 04/2006)
2.	Whitcomb, David C: 2 articles (01/2015 - 01/2010)
3.	Férec, Claude: 2 articles (01/2013 - 02/2008)
4.	Masson, Emmanuelle: 2 articles (01/2013 - 02/2008)
5.	Geisz, Andrea: 1 article (01/2019)
6.	Hegyi, Eszter: 1 article (01/2019)
7.	Jancsó, Zsanett: 1 article (01/2019)
8.	Németh, Balázs Csaba: 1 article (01/2019)
9.	Bal, Jerzy: 1 article (12/2017)
10.	Gluszek, Stanislaw: 1 article (12/2017)

Related Diseases

1.	Chronic Pancreatitis 12/01/2017 - "Genetic studies in adults/adolescent patients with chronic pancreatitis (CP) identified chymotrypsinogen C (CTRC) genetic variants but their association with CP risk has been difficult to replicate. " 12/01/2017 - "Chymotrypsinogen C Genetic Variants, Including c.180TT, Are Strongly Associated With Chronic Pancreatitis in Pediatric Patients." 03/01/2010 - "Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. " 02/01/2008 - "Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis." 01/08/2015 - "The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population."
2.	Cystic Fibrosis (Mucoviscidosis) 01/01/2011 - "Either disease-causing or protective traits have been indentified for mutations in different trypsinogen genes, the gene for the trypsin inhibitor SPINK1, chymotrypsinogen C, and the cystic fibrosis transmembane conductance regulator (CFTR). " 11/15/2014 - "Candidate gene and genetic linkage studies have identified polymorphisms in cationic trypsinogen (PRSS1), SPINK1, cystic fibrosis trans-membrane conductance regulator (CFTR), Chymotrypsinogen C (CTRC), Cathepsin B (CTSB) and calcium sensing receptor (CASR). "
3.	Pancreatitis 03/01/2010 - "Pancreatitis-associated CTRC mutations can markedly increase the propensity of chymotrypsinogen C to elicit ER stress in pancreatic acinar cells. " 03/01/2010 - "Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells." 04/28/2006 - "Furthermore, inappropriate activation of chymotrypsinogen C in the pancreas may contribute to the development of pancreatitis. " 01/08/2015 - "The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population." 01/01/2019 - "Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice."
4.	Tropical Calcific Pancreatitis 03/01/2011 - "A loss-of-function alteration in chymotrypsinogen C (CTRC) gene has been shown to be associated with tropical calcific pancreatitis (TCP). "

Related Drugs and Biologics

1.	Trypsinogen
2.	Kazal Pancreatic Trypsin Inhibitor
3.	Calcium-Sensing Receptors
4.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
5.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
6.	Cathepsin B
7.	Trypsin Inhibitors
8.	Nucleotides
9.	Secretagogues