nociceptin

a 17-amino acid-long peptide from rat brain; resembles dynorphin A; an endogenous agonist of the opioid receptor-like ORL1 receptor; amino acid sequence given in first & second source; GenBank AF348323 (human)

Also Known As:

Networked: 391 relevant articles (11 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Guerrini, Remo: 11 articles (11/2015 - 02/2002)
2.	Romualdi, Patrizia: 10 articles (08/2015 - 11/2002)
3.	Candeletti, Sanzio: 10 articles (08/2015 - 11/2002)
4.	Morari, Michele: 10 articles (09/2014 - 10/2005)
5.	Armstead, William M: 10 articles (02/2011 - 08/2002)
6.	Armstead, W M: 10 articles (07/2001 - 02/2000)
7.	Marti, Matteo: 9 articles (11/2012 - 10/2005)
8.	Ciccocioppo, Roberto: 8 articles (07/2015 - 05/2002)
9.	Massi, Maurizio: 7 articles (07/2013 - 05/2002)
10.	Wu, Gen-Cheng: 7 articles (03/2010 - 01/2002)

Related Diseases

1.	Hyperalgesia 11/01/1999 - "Nociceptin (3.0 fmol) produced a significant reduction in the nociceptive thermal threshold (hyperalgesia) measured as the tail-flick and paw-withdrawal responses. " 04/18/1997 - "In the present study, we investigated the effect of intrathecally administered nociceptin on the level of thermal hyperalgesia induced by carageenan injection in the rat. " 03/14/1997 - "In the present study, we investigated the effect of intrathecally administered nociceptin on the level of thermal hyperalgesia after unilateral constriction injury to the sciatic nerve in the rat. " 01/08/2008 - "These results suggest that the spinal nociceptin system is involved in the transitional process from herpetic allodynia to postherpetic allodynia." 07/01/2004 - "Although hyperalgesia was fully present after 5 days, no changes in nociceptin immunoreactivity in the lumbar spinal cord were detected at this time point. "
2.	Inflammation 06/01/1998 - "Peripheral inflammation and nerve injury may induce spinal plasticity which leads to altered potency and efficacy of nociceptin." 01/01/2001 - "The present study investigates the effect of nociceptin on synovial plasma extravasation and its ability to modulate 5-hydroxytryptamine-induced synovial plasma extravasation using the rat knee joint model of inflammation. " 11/01/2009 - "Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation." 07/01/2001 - "The results suggest that peripheral inflammation induces the production of nociceptin in a sub-population of VR1-positive primary sensory neurons and support the idea that nociceptin produced there is involved in the regulation of nociceptive processing." 07/01/2000 - "Supporting this hypothesis, several groups have shown that intrathecal nociceptin alleviated hyperalgesic and allodynic responses in rats after inflammation or partial peripheral nerve injury. "
3.	Pain (Aches) 01/28/2008 - "The aim of the present study was to clarify the role of nociceptin system in pain modulation. " 09/16/2002 - "This study aimed to define the change of serum level of nociceptin in pain patients. " 06/22/2001 - "The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. " 01/05/2001 - "The aim of the present study was to examine the effect of microinjection of orphanin FQ (OFQ) into periaqueductal gray (PAG) on sensory processing in the wide dynamic range (WDR) neurons of the spinal dorsal horn and to explore the effect of OFQ on a descending system of pain modulation. " 01/01/2000 - "In the present study, we designed experiments to elucidate the pathways and mediators of nociceptin-evoked pain responses. "
4.	Sepsis (Septicemia) 11/01/2014 - "Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system." 11/01/2014 - "We evaluated the suitability of an experimental lipopolysaccharide (LPS)-induced sepsis model for studying changes in the nociceptin system. " 10/01/2014 - "This review details the known effects of NOP activation on leucocytes and the vascular endothelium and discusses the most recent human and animal data on the role of the nociceptin system in sepsis. " 10/01/2014 - "As there is a loss of regulation of inflammatory responses during sepsis, the nociceptin system could be a target for therapies aimed at modulating sepsis. " 10/01/2014 - "Nociceptin system as a target in sepsis?"
5.	Parkinsonian Disorders (Parkinsonism) 03/10/2010 - "Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice." 09/24/2014 - "Stimulation of δ opioid receptor and blockade of nociceptin/orphanin FQ receptor synergistically attenuate parkinsonism." 12/01/2010 - "The contribution of nociceptin/orphanin FQ (N/OFQ) to reserpine-induced Parkinsonism was evaluated in mice. " 06/01/2010 - "The novel nociceptin/orphanin FQ receptor (NOP) antagonist 1-[1-(cyclooctylmethyl)-1,2,3,6-tetrahydro-5-(hydroxymethyl)-4-pyridinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (Trap-101, 0.001-0.1 mg/kg), an analogue of 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397), also promoted stepping and synergistically or additively (depending on test) attenuated parkinsonism when combined to dopamine agonists. " 03/10/2010 - "The contribution of endogenous nociceptin/orphanin FQ (N/OFQ) to neuroleptic-induced parkinsonism has been evaluated in haloperidol-treated mice. "

Related Drugs and Biologics

1.	nociceptin
2.	Opioid Receptors (Opioid Receptor)
3.	Capsaicin (Zostrix)
4.	Dextrans (Dextran)
5.	sodium sulfate (sodium bisulfate)
6.	nociceptin receptor
7.	N-Methylaspartate (NMDA)
8.	Morphine (MS Contin)
9.	Formaldehyde (Formol)
10.	Opioid Peptides (Opioid Peptide)

Related Therapies and Procedures

1.	Analgesia
2.	Ligation
3.	Spinal Injections
4.	Electroacupuncture
5.	Injections