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taxa-4(5),11(12)-diene synthase (taxadiene synthase)

catalyzes the cyclization of geranylgeranyl pyrophosphate to taxa-4(5),11(12)-diene, the first step to taxol biosynthesis

Also Known As:

taxadiene synthase; taxadiene cyclase

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - taxa-4(5),11(12)-diene synthase: 3

Experts

1.	Guo, B: 1 article (01/2009)
2.	Miao, Z: 1 article (01/2009)
3.	Tang, K: 1 article (01/2009)
4.	Wang, Y: 1 article (01/2009)
5.	Yu, X: 1 article (01/2009)
6.	Coates, R M: 1 article (07/2000)
7.	Croteau, R: 1 article (07/2000)
8.	Dalal, D: 1 article (07/2000)
9.	Jin, A Q: 1 article (07/2000)
10.	Oliver, J S: 1 article (07/2000)

Related Diseases

1.	Wounds and Injuries (Trauma) 10/01/1995 - "The activity (and enzyme protein) levels of Pacific yew taxadiene synthase are much lower than those for abietadiene synthase of lodgepole pine stem (constitutive) or of grand fir stem (wound-inducible) and the enzyme is not inducible to higher levels by stem wounding or elicitor treatment."
2.	Neoplasms (Cancer) 07/01/2000 - "The diterpene cyclase taxadiene synthase from yew (Taxus) species transforms geranylgeranyl diphosphate to taxa-4(5),11(12)-diene as the first committed step in the biosynthesis of the anti-cancer drug Taxol. "
3.	Carcinoma (Carcinomatosis) 01/01/2009 - "The presence of taxol and its important precursors, such as 10-diacetyl baccatinIII (10-DAB) and baccatinIII, in the culture of this fungus was confirmed by reactivity with taxane-specific monoclonal antibody, comparative chromatographic and mass spectrometric behavior, cytotoxity to liver carcinoma 7402, and molecular cloning of kernel fragment of taxadiene synthase gene."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Proteins (Proteins, Gene)
3.	Enzymes
4.	Diterpenes
5.	Monoclonal Antibodies
6.	abietadiene cyclase
7.	taxane
8.	geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)