(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid

a GABA-B receptor antagonist; structure given in first source

Also Known As:

2-morpholineacetic acid, 5,5-dimethyl-, hydrochloride, (2R)-; 2-morpholineacetic acid, 5,5-dimethyl-, hydrochloride, (2S)-; 5,5-dimethyl-2-morpholineacetic acid hydrochloride; SCH 50910; SCH 50911; SCH-50910; SCH-50911

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid: 6

Experts

1.	Carai, Mauro A M: 3 articles (02/2008 - 06/2002)
2.	Colombo, Giancarlo: 3 articles (02/2008 - 06/2002)
3.	Gessa, Gian Luigi: 3 articles (02/2008 - 06/2002)
4.	Lobina, Carla: 3 articles (02/2008 - 06/2002)
5.	Maccioni, Paola: 2 articles (02/2008 - 08/2006)
6.	Ali, S F: 1 article (03/2011)
7.	Bach, J-H: 1 article (03/2011)
8.	Jang, C G: 1 article (03/2011)
9.	Jung, B-D: 1 article (03/2011)
10.	Kim, H-C: 1 article (03/2011)

Related Diseases

1.	Seizures (Absence Seizure) 09/01/1995 - "SCH 50911 abolished seizures in all three models in a dose-dependent fashion (ID100 = 8-170 mumol/kg). " 08/01/2006 - "Conversely, sP rats displayed both spontaneous and precipitated audiogenic seizures following abrupt cessation of chronic GHB or 1,4-BD administration and following pharmacological challenge with the GABA(B) receptor-selective antagonist, SCH 50911, respectively." 09/01/1995 - "In this study we measured the antiabsence effects of SCH 50911 in three animal models: the lethargic (lh/lh) mutant mouse, which has spontaneous absence seizures; and two rat models in which absence seizures were induced by administration of either gamma-hydroxybutyrate or pentylenetetrazole. " 06/12/2002 - "The present study investigated the effect of the GABA(B) receptor antagonist, SCH 50911 [(2S)(+)-5,5-dimethyl-2-morpholineacetic acid], on the occurrence of seizures in ethanol-dependent rats undergoing ethanol withdrawal syndrome. " 03/01/2011 - "GE-mediated attenuations on the cocaine-induced seizures and CPP were significantly reversed by bicuculline (0.25 or 0.5 mg/kg, i.p.), but not by SCH 50911 (1.5 or 3.0 mg/kg, i.p.). "
2.	Hypothermia 05/01/2004 - "However, SCH 50911 (1-10 mg/kg ip), a GABA(B) blocker, did not antagonize the hypothermia. "
3.	Ataxia (Dyssynergia) 02/01/2008 - "To this aim, DBA mice were pretreated either with GABA(B)-receptor antagonists, (3-aminopropyl)(diethoxymethyl)phosphinic acid (CGP 35348) and (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), or a putative antagonist of the specific-GHB binding site, 6,7,8,9-tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid (NCS-382), prior to the administration of doses of GBL that induced hypothermia, motor-incoordination (measured as motor-impairment at the Rota-Rod task), and sedation/hypnosis. "

Related Drugs and Biologics

1.	GABA-B Receptor Antagonists
2.	Acids
3.	Sodium Oxybate (gamma Hydroxybutyrate)
4.	Pentylenetetrazole (Metrazol)
5.	Ethanol (Ethyl Alcohol)
6.	GABA-B Receptors
7.	gamma-Aminobutyric Acid (GABA)
8.	Cocaine (Cocaine HCl)
9.	Bicuculline
10.	CGP 35348

Related Therapies and Procedures

1.	Induced Hypothermia
2.	Hypnosis (Mesmerism)