E 3040 (E3040)

a dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase; structure given in first source

Also Known As:

E3040; 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole; E-3040; E3040 sulfate

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        E 3040: 6
  - Pyridines: 88
    - E 3040: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - E 3040: 6

Experts

1.	Jonker, Johan W: 1 article (09/2004)
2.	Kusuhara, Hiroyuki: 1 article (09/2004)
3.	Mizuno, Naomi: 1 article (09/2004)
4.	Niwa, Takuro: 1 article (09/2004)
5.	Sugiyama, Yuichi: 1 article (09/2004)
6.	Suzuki, Hiroshi: 1 article (09/2004)
7.	Suzuki, Michiko: 1 article (09/2004)
8.	Takeuchi, Kenji: 1 article (09/2004)
9.	Harada, K: 1 article (06/2001)
10.	Inoue, T: 1 article (06/2001)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/01/1999 - "Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice." 03/01/1999 - "Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia." 10/06/2000 - "Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles."
2.	Hyperuricemia 03/01/1999 - "In the present study, the mechanism of the uricosuric action of E3040 was investigated using the hyperuricemia model rat. " 03/01/1999 - "Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia."
3.	Leukemia 06/22/2001 - "Against the 5-lipoxygenase activity of rat basophilic leukemia cells, E3040 and zileuton (a 5-lipoxygenase inhibitor) had an IC(50) of 0.23 and 0.93 microM, respectively. "
4.	Colitis 09/16/1994 - "When some of these compounds (8, 13a, 26a (E3040), 26b, 27b, and 28b) were orally administered in the rat TNB/ethanol-induced chronic colitis model (100 mg/kg), the production of both LTB4 and TXB2 in the rat colon was reduced (ex vivo). "
5.	Breast Neoplasms (Breast Cancer) 09/01/2004 - "Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice."

Related Drugs and Biologics

1.	Lipoxygenase Inhibitors
2.	Uric Acid (Urate)
3.	Proteins (Proteins, Gene)
4.	Leukotriene B4
5.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
6.	Ethanol (Ethyl Alcohol)
7.	zileuton (Zyflo)
8.	benzothiazole