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1-aminoindan-1,5-dicarboxylic acid

structure given in first source

Also Known As:

(RS)-aminoindan-1,5-dicarboxylic Acid; 1-AI-1,5-DCA; AIDA compound

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        1-aminoindan-1,5-dicarboxylic acid: 7
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - 1-aminoindan-1,5-dicarboxylic acid: 7

Experts

1.	Ferraraccio, Franca: 1 article (03/2008)
2.	Fuccio, Carlo: 1 article (03/2008)
3.	Giordano, Catia: 1 article (03/2008)
4.	Luongo, Livio: 1 article (03/2008)
5.	Maione, Sabatino: 1 article (03/2008)
6.	Rossi, Francesca: 1 article (03/2008)
7.	Roth, Kevin A: 1 article (03/2008)
8.	Siniscalco, Dario: 1 article (03/2008)
9.	de Novellis, Vito: 1 article (03/2008)
10.	Carmant, Lionel: 1 article (11/2002)

Related Diseases

1.	Ischemia 10/20/2000 - "To elucidate the role of group I mGluR, we tested the effects of (S)-alpha-methyl-4-carboxy-phenylglycine (MCPG, mGluR 1 and 5 antagonist), 1-aminoindan-1,5-dicarboxylic acid (AIDA, mGluR 1a specific antagonist) and 2-methyl-6-(phenylethynyl) pyridine (MPEP, mGluR 5 antagonist) on ArAc release and neuronal survival after transient forebrain ischemia in gerbils. " 10/01/1999 - "In order to study the role of metabotropic glutamate 1 (mGlu1) receptors in ischemic neuronal death, we examined the effects of the recently characterized and relatively selective mGlu1 receptor antagonists 1-aminoindan-1,5-dicarboxylic acid (AIDA) and (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) in murine cortical cell cultures and rat organotypic hippocampal slices exposed to oxygen glucose deprivation (OGD) and in vivo, following transient global ischemia in gerbils. "
2.	Spinal Cord Injuries (Spinal Cord Injury) 09/28/2000 - "To test contributions of group I metabotropic glutamate receptors (mGluRs) in SCI induced release of glutamate and in behavioral outcomes of central sensitization following injury, we administered 1-aminoindan-1,5-dicarboxylic acid (AIDA; 0.1 nmol intraspinally), a potent group I mGluR antagonist, to rats immediately after spinal cord contusion injury. "
3.	Seizures (Absence Seizure) 12/01/1998 - "The group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) dose-dependently antagonised PTZ-induced seizures with a mean ED50 value of 465 nmol. "
4.	Hyperalgesia 03/01/2008 - "The effect of the non-selective, 1-aminoindan-1,5-dicarboxylic acid (AIDA), and selective (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone (JNJ16259685), metabotropic glutamate subtype 1 (mGlu1) receptor antagonists, on rat sciatic nerve chronic constrictive injury (CCI)-induced hyperalgesia, allodynia, spinal dorsal horn apoptosis, and gliosis was examined at 3 and 7 days post-injury. "
5.	Gliosis 03/01/2008 - "The effect of the non-selective, 1-aminoindan-1,5-dicarboxylic acid (AIDA), and selective (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone (JNJ16259685), metabotropic glutamate subtype 1 (mGlu1) receptor antagonists, on rat sciatic nerve chronic constrictive injury (CCI)-induced hyperalgesia, allodynia, spinal dorsal horn apoptosis, and gliosis was examined at 3 and 7 days post-injury. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Oxygen (Dioxygen)
3.	Glycine (Aminoacetic Acid)
4.	Glucose (Dextrose)
5.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
6.	(3,4- dihydro- 2H- pyrano(2,3)b- quinolin- 7- yl)- (cis- 4- methoxycyclohexyl) methanone
7.	pyridine