HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1,5-dihydroxyisoquinoline

structure in first source

Also Known As:

1,5-isoquinolinediol

Networked: 12 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 1,5-dihydroxyisoquinoline: 12

Experts

1.	Sharma, Shyam S: 2 articles (04/2016 - 10/2004)
2.	Bermudez Sanchez, Sandra: 1 article (01/2021)
3.	German, Alexander J: 1 article (01/2021)
4.	Gramenzi, Alessandro: 1 article (01/2021)
5.	Lidbury, Jonathan A: 1 article (01/2021)
6.	Marsilio, Fulvio: 1 article (01/2021)
7.	Pilla, Rachel: 1 article (01/2021)
8.	Sarawichitr, Benjamin: 1 article (01/2021)
9.	Steiner, Joerg M: 1 article (01/2021)
10.	Suchodolski, Jan S: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 03/01/1996 - "An inhibitor of poly (ADP-ribose) polymerase, 1,5-dihydroxyisoquinoline (DHIQ), evaluated in vivo against a murine advanced breast cancer, significantly improved by 20% the PR rate of tumor-regressing chemotherapy. " 10/01/2003 - "The administration of PARP inhibitors, 3-aminobenzamide or 1,5-isoquinolinediol, to FsaR tumor-bearing mice before PDT light treatment increased the resistance of these tumors to PDT. "
2.	Breast Neoplasms (Breast Cancer) 03/01/1996 - "An inhibitor of poly (ADP-ribose) polymerase, 1,5-dihydroxyisoquinoline (DHIQ), evaluated in vivo against a murine advanced breast cancer, significantly improved by 20% the PR rate of tumor-regressing chemotherapy. "
3.	Myocardial Ischemia (Ischemic Heart Diseases) 03/01/2005 - "In this study, we investigated the biological effects and the molecular mechanisms of two structurally unrelated selective inhibitors of PARP-1, 3-aminobenzamide (3-AB) and 1,5-dihydroxyisoquinoline (-DIQ), in an in vivo model of myocardial ischemia and reperfusion. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/01/2004 - "The authors evaluated the neuroprotective effect of 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato-iron(III) (FeTMPyP), a peroxynitrite decomposition catalyst, and 1,5-isoquinolinediol (ISO), a poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor, alone and in combination in rats with focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO). "
5.	Weight Loss (Weight Reduction) 01/01/2021 - "Conversely, the polyphenols (-)-epicatechin and matairesinol and the quinoline derivatives 1,5-isoquinolinediol and 2-hydroxiquinoline increased after weight loss. "

Related Drugs and Biologics

1.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
2.	3-aminobenzamide
3.	Poly(ADP-ribose) Polymerase Inhibitors
4.	Niacinamide (Nicotinamide)
5.	salicylhydroxamic acid (SHAM)
6.	Polyphenols
7.	Peroxynitrous Acid (Peroxynitrite)
8.	Neuroprotective Agents
9.	Cyclosporine (Ciclosporin)
10.	Poly Adenosine Diphosphate Ribose

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Resuscitation