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1,4- bis(4- methoxyphenyl)- 3- (3- phenylpropyl)- 2- azetidinone

an inhibitor of cholesterol absorption; structure given in first source

Also Known As:

SCH 48461; SCH-48461

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azetines
    - Azetidines: 6
      - 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone: 2

Experts

1.	Alton, K B: 1 article (10/2001)
2.	Burrier, R E: 1 article (10/2001)
3.	Davis, H R: 1 article (10/2001)
4.	Pula, K K: 1 article (10/2001)
5.	Watkins, R W: 1 article (10/2001)
6.	Bays, H: 1 article (01/2001)
7.	Cuffie-Jackson, C: 1 article (01/2001)
8.	Davidson, M H: 1 article (01/2001)
9.	Dujovne, C A: 1 article (01/2001)
10.	Goldberg, A C: 1 article (01/2001)

Related Diseases

1.

Hypercholesterolemia

01/01/2001 - "This study demonstrated a clinically and statistically significant cholesterol-lowering effect of SCH 48461 in patients with primary hypercholesterolemia."
01/01/2001 - "Reduction of LDL cholesterol in patients with primary hypercholesterolemia by SCH 48461: results of a multicenter dose-ranging study."
01/01/2001 - "SCH 48461, an inhibitor of gastrointestinal absorption of cholesterol, was evaluated for its effects on lipid parameters in patients with primary hypercholesterolemia in a multicenter, double-blind, randomized, parallel-group study. "
10/01/2001 - "Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which cause significant decreases in plasma cholesterol levels in cholesterol-fed animals and in humans with hypercholesterolemia. "

Related Drugs and Biologics

1.	Cholesterol
2.	LDL Cholesterol
3.	Lipids
4.	Ezetimibe (Zetia)