4- aminobenzoyl- glycyl- prolyl- leucyl- alanine hydroxamic acid

inhibits collagenase; structure in first source

Also Known As:

FN 439; FN-439; H2N-C6H4-CO-Gly-Pro-Leu-Ala-NHOH; MMP-inhibitor I; p-NH2-Bz-Gly-Pro-D-Leu-D-Ala-NHOH

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid: 7
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid: 7
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid: 7

Experts

1.	Dobolyi, Arpád: 1 article (04/2016)
2.	Lakatos, Kinga: 1 article (04/2016)
3.	Merkely, Béla: 1 article (04/2016)
4.	Nagy, Zoltán: 1 article (04/2016)
5.	Nardai, Sándor: 1 article (04/2016)
6.	Skopál, Judit: 1 article (04/2016)
7.	Cybulska-Klosowicz, A: 1 article (06/2011)
8.	Kossut, M: 1 article (06/2011)
9.	Liguz-Lecznar, M: 1 article (06/2011)
10.	Nowicka, D: 1 article (06/2011)

Related Diseases

1.	Shock 01/01/2009 - "The goal of this study was to determine the extent to which FN-439 would disrupt the consolidation and/or reconsolidation of a fear memory associated with a conditioned stimulus that signaled tone-shock pairings and that was independent of contextual cues. " 01/01/2009 - "Male Sprague-Dawley rats were given infusions of FN-439 (35 microg intracerebroventricular) 30 min prior to conditioning (tone-shock paired association) or 30 min prior to a single reactivation session given 24h after conditioning. "
2.	Stroke (Strokes) 04/01/2016 - "Gelatinase inhibition was achieved by intracerebral injection of the Fn-439 MMP inhibitor 7 days after stroke. " 06/01/2011 - "However, when mice were injected with the broad-spectrum inhibitor of MMPs FN-439 (10 mg/kg, i.v.) immediately before a stroke, an enlargement of the representation of the spared row similar to the enlargement found in sham mice was observed. "
3.	Ulcer 01/01/1995 - "FN-439 may be useful for treating noninfectious corneal ulcers because of its potent activity (IC50 = 1 microM) and chemical and biological stabilities."
4.	Necrosis 08/01/2004 - "Addition of the broad-spectrum matrix metalloprotease (MMP)-inhibitor FN 439, neutralizing MMP-9 or tumour necrosis factor-alpha (TNF-alpha) antibodies reduced invasiveness to basal levels. "
5.	Infarction (Infarctions) 09/04/2008 - "The inhibition of matrix metalloproteinases (MMPs) using the MMP inhibitor, FN-439, decreased nestin-positive cells in the peri-infarct region at 7 days after photothrombosis. "

Related Drugs and Biologics

1.	Matrix Metalloproteinase Inhibitors
2.	Matrix Metalloproteinases (MMPs)
3.	Nestin
4.	Metalloproteases (Metalloproteinases)
5.	Gelatinases
6.	Collagenases (Collagenase)
7.	Ofloxacin (Ofloxacine)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Antibodies
10.	salicylhydroxamic acid (SHAM)