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4- aminobenzoyl- glycyl- prolyl- leucyl- alanine hydroxamic acid

Subscribe to New Research on 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid

inhibits collagenase; structure in first source

Also Known As:

FN 439; FN-439; H2N-C6H4-CO-Gly-Pro-Leu-Ala-NHOH; MMP-inhibitor I; p-NH2-Bz-Gly-Pro-D-Leu-D-Ala-NHOH

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ziemka-Nalecz, M: 1 article (06/2011)
2.	Skangiel-Kramska, J: 1 article (06/2011)
3.	Cybulska-Klosowicz, A: 1 article (06/2011)
4.	Liguz-Lecznar, M: 1 article (06/2011)
5.	Nowicka, D: 1 article (06/2011)
6.	Kossut, M: 1 article (06/2011)
7.	Sorg, Barbara A: 1 article (01/2009)
8.	Wilson, Adrianne R: 1 article (01/2009)
9.	Brown, Travis E: 1 article (01/2009)
10.	Cocking, Davelle L: 1 article (01/2009)

Related Diseases

1.	Shock 01/01/2009 - "The goal of this study was to determine the extent to which FN-439 would disrupt the consolidation and/or reconsolidation of a fear memory associated with a conditioned stimulus that signaled tone-shock pairings and that was independent of contextual cues. " 01/01/2009 - "Male Sprague-Dawley rats were given infusions of FN-439 (35 microg intracerebroventricular) 30 min prior to conditioning (tone-shock paired association) or 30 min prior to a single reactivation session given 24h after conditioning. "
2.	Stroke (Strokes) 06/01/2011 - "However, when mice were injected with the broad-spectrum inhibitor of MMPs FN-439 (10 mg/kg, i.v.) immediately before a stroke, an enlargement of the representation of the spared row similar to the enlargement found in sham mice was observed. "
3.	Ulcer 01/01/1995 - "FN-439 may be useful for treating noninfectious corneal ulcers because of its potent activity (IC50 = 1 microM) and chemical and biological stabilities."
4.	Necrosis 08/01/2004 - "Addition of the broad-spectrum matrix metalloprotease (MMP)-inhibitor FN 439, neutralizing MMP-9 or tumour necrosis factor-alpha (TNF-alpha) antibodies reduced invasiveness to basal levels. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Antibodies
4.	salicylhydroxamic acid (SHAM)