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2-hydroxydeoxyadenosine triphosphate

Also Known As:

2-OH-dATP; 2-hydroxy-2'-deoxyadenosine 5'-triphosphate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Adenosine Triphosphate: 27668
        2-hydroxydeoxyadenosine triphosphate: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        2-hydroxydeoxyadenosine triphosphate: 2
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        2-hydroxydeoxyadenosine triphosphate: 2

Experts

1.	Nakabeppu, Yusaku: 2 articles (04/2006 - 09/2003)
2.	Sakumi, Kunihiko: 2 articles (04/2006 - 09/2003)
3.	Nakatsu, Yoshimichi: 1 article (04/2006)
4.	Sakamoto, Katsumi: 1 article (04/2006)
5.	Tsuchimoto, Daisuke: 1 article (04/2006)
6.	Tsuzuki, Teruhisa: 1 article (04/2006)
7.	Furuichi, Masato: 1 article (09/2003)
8.	Iwai, Shigenori: 1 article (09/2003)
9.	Ohno, Mizuki: 1 article (09/2003)
10.	Sakai, Yasunari: 1 article (09/2003)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 09/26/2003 - "Human MTH1 thus protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP, and these alterations may be partly attributed to a mitochondrial dysfunction."
2.	Autosomal Recessive Colorectal Adenomatous Polyposis 04/01/2006 - "MUTYH deficiency may also increase G:C to T:A transversions through the misincorporation of 2-OH-dATP, especially in the intestinal tract, since MUTYH can excise 2-hydroxyadenine opposite guanine in genomic DNA and the repair activity is selectively impaired by a mutation found in patients with autosomal recessive colorectal adenomatous polyposis."

Related Drugs and Biologics

1.	Purine Nucleotides
2.	Guanine
3.	DNA (Deoxyribonucleic Acid)
4.	8-oxodeoxyguanosine triphosphate
5.	isoguanine