BA 41899

a 1,5-benzodiazocine derivative; a positive inotropic Ca(2+)-sensitizing agent; CGP-48506 is the (+)-isomer; CGP-48508 is the (-)-isomer; structure given in first source

Also Known As:

5-methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4-dione; BA 41899, (3R)-isomer; BA 41899, (3S)-isomer; BA-41899; CGP 48506; CGP 48508; CGP-48506; CGP-48508

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azocines
    - BA 41899: 4

Experts

1.	Brixius, K: 2 articles (04/2002 - 12/2000)
2.	Minami, Hiroaki: 1 article (05/2008)
3.	Solaro, R John: 1 article (05/2008)
4.	Stojanovic, Miroslav O: 1 article (05/2008)
5.	Wolska, Beata M: 1 article (05/2008)
6.	Reicke, S: 1 article (04/2002)
7.	Reuter, H: 1 article (04/2002)
8.	Schwinger, R H G: 1 article (04/2002)
9.	Egashira, K: 1 article (01/2001)
10.	Hayashidani, S: 1 article (01/2001)

Related Diseases

1.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 12/01/2000 - "To study the mode of action of the Ca(2+) sensitizers EMD 57033 (EMD) and CGP 48506 (CGP), their influence on butanedione monoxime (BDM)-mediated depression of cross-bridge cycling was analyzed in human myocardium (explanted hearts, dilated cardiomyopathy, n = 19). "
2.	Heart Failure 04/01/2002 - "Ca2+ sensitizers like EMD 57033 (EMD) and CGP 48506 (CGP) may be advantageous for the treatment of human heart failure, as they increase force of contraction without increasing the intracellular Ca2+ transients or energy consumption. " 01/01/2001 - "CGP 48506 and EMD 57033 exerted a positive inotropic effect in a dose (0.1-3 microM)-dependent manner in both normal and heart failure myocytes. "
3.	Acidosis 05/01/2008 - "In experiments reported here, we tested the ability of CGP-48506 to reverse the depressed cardiac contractility associated with hypercapnic acidosis in isolated rat cardiac myocytes. " 05/01/2008 - "Reversal of effects of acidosis on contraction of rat heart myocytes by CGP-48506."

Related Drugs and Biologics

1.	EMD 53998
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