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5-ethoxy-2'-deoxyuridine

a substrate for the transferase reaction of thymidine phosphorylase; structure given in first source

Also Known As:

5-EOdU; 5-ethoxy-dUrd

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Uridine: 1186
        Deoxyuridine: 331
        5-ethoxy-2'-deoxyuridine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Uridine: 1186
      - Deoxyuridine: 331
        5-ethoxy-2'-deoxyuridine: 1
  - Deoxyribonucleosides: 34
    - Deoxyuridine: 331
      - 5-ethoxy-2'-deoxyuridine: 1

Related Diseases

1.

Carcinoma (Carcinomatosis)

08/15/1995 - "One of the compounds, the novel pyrimidine analogue 5-ethoxy-2'-deoxyuridine (EOdU), was found to be a substrate for the transferase reaction of TP, to have little or no direct cytotoxicity, to selectively increase the cellular levels of 5-fluoro-dUMP, to enhance the inhibitory effect of FUra on thymidylate synthase activity, and to potentiate the cytotoxicity of FUra and IFN in human colon carcinoma cells. "

Related Drugs and Biologics

1.	Transferases
2.	Thymidylate Synthase
3.	pyrimidine