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protegrin-1

GenBank X84094

Also Known As:

PG-1 protegrin; protegrin PG-1

Networked: 22 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        protegrin-1: 22
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - protegrin-1: 22
  - Antimicrobial Cationic Peptides: 414
    - protegrin-1: 22

Experts

1.	Li, Julang: 2 articles (08/2021 - 05/2008)
2.	Daniell, Henry: 2 articles (10/2015 - 01/2011)
3.	Steinstraesser, Lars: 2 articles (01/2012 - 01/2003)
4.	Steinstraesser, L: 2 articles (03/2007 - 07/2001)
5.	Alaverdian, Diana A: 1 article (01/2022)
6.	Chernov, Alexandr N: 1 article (01/2022)
7.	Filatenkova, Tatiana A: 1 article (01/2022)
8.	Galimova, Elvira S: 1 article (01/2022)
9.	Shamova, Olga V: 1 article (01/2022)
10.	Suvorov, Alexander N: 1 article (01/2022)

Related Diseases

1.	Burns 07/01/2001 - "The objective of this study was to examine the efficacy of protegrin-1 in killing multiple drug-resistant microbes isolated from human burn patients. " 07/01/2001 - "For thein vitroexperiment, bilayer radial diffusion was performed comparing standard antibiotics with protegrin-1 on multiple-drug-resistant microbial organisms isolated from infected burn wounds. "
2.	Virus Diseases (Viral Diseases) 10/06/2015 - "Preclinical evaluation of Retrocyclins (RC-100, RC-101) and Protegrin-1 (PG-1) antimicrobial peptides (AMPs) is important because of their therapeutic potential against bacterial, fungal and viral infections. " 01/01/2011 - "Retrocyclin-101 (RC101) and Protegrin-1 (PG1) are two important antimicrobial peptides that can be used as therapeutic agents against bacterial and/or viral infections, especially those caused by the HIV-1 or sexually transmitted bacteria. "
3.	Fibrosarcoma 01/01/2012 - "Cell proliferation of the fibrosarcoma cell line, HT1080, and human fibroblasts was determined in vitro after treatment with [D]-K(6)L(9), [D]-K(3)H(3)L(9), and Protegrin-1. " 01/01/2012 - "Our aim was to assess the toxic efficacy of [D]-K(6)L(9), [D]-K(3)H(3)L(9), and Protegrin-1 against the fibrosarcoma cell line, HT1080, and primary human fibroblasts to analyze the potential of these peptides as therapeutic options against STSs. "
4.	Infections 08/31/2021 - "Protective and Anti-Inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice." 01/01/2023 - "In this study, we propose and demonstrate a novel repurposing strategy for an antimicrobial peptide of protegrin-1 (PG-1), which exhibits the ability to simultaneously prevent Aβ aggregation and microbial infection both in vitro and in vivo. " 04/02/2007 - "Protegrin-1 (PG-1) is known as a potent antibiotic peptide; it prevents infection via an attack on the membrane surface of invading microorganisms. " 09/01/2017 - "We demonstrate that LL-37, the porcine cathelicidin Protegrin-1, and the ovine cathelicidin SMAP-29 display potent antiviral activity towards HRV and that this activity is visible when either the virus is exposed to the peptides prior to cell infection or after cells have been infected. "
5.	Wound Infection (Wound Infections) 07/01/2001 - "This study shows that protegrin-1 potentially may be used as an alternative or adjunct therapy to standard agents used to treat wound infections." 03/01/2007 - "After wound infection had been established (4 days after inoculation), each wound chamber was topically treated with P-novispirin G10, protegrin-1 or carrier control. "

Related Drugs and Biologics

1.	Antimicrobial Peptides
2.	Peptides (Polypeptides)
3.	Cathelicidins
4.	Nerve Growth Factor (NGF)
5.	Antiviral Agents (Antivirals)
6.	Temozolomide (Temodar)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Adenosine Monophosphate (AMP)
9.	Serine Proteases (Serine Protease)
10.	Histatins

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)