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L 701324

a glycine/NMDA receptor antagonist
Also Known As:
7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolone; L 701,324; L-701,324; L-701324; 2(1H)-quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-
Networked: 16 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Aronica, Eleonora: 1 article (05/2014)
2. Gorter, Jan: 1 article (05/2014)
3. Potschka, Heidrun: 1 article (05/2014)
4. Salvamoser, Josephine D: 1 article (05/2014)
5. Soerensen, Jonna: 1 article (05/2014)
6. Zellinger, Christina: 1 article (05/2014)
7. van Vliet, Erwin A: 1 article (05/2014)
8. Camp, Marguerite: 1 article (02/2013)
9. Debrouse, Lauren: 1 article (02/2013)
10. Grant, Seth G N: 1 article (02/2013)

Related Diseases

1. Catalepsy
2. Seizures (Absence Seizure)
05/01/2014 - "A low dosage of phenobarbital caused a significant increase of the generalized seizure threshold in the L-701,324 pre-treated group, whereas it did not exert a comparable effect in animals that received vehicle during the massive kindling phase. "
11/01/1996 - "In mice, L-701,324 protected against seizures induced by N-methyl-DL-aspartate (ED50 = 3,4 mg/kg i.v.), pentylenetetrazol (ED50 = 2.8 mg/kg i.v.) and electroshock (ED50 = 1.4 mg/kg i.v.) but was most potent against audiogenic seizures in DBA/2 mice (ED50 = 0.96 mg/kg i.p.). "
10/01/1996 - "The inhibition of ethanol withdrawal seizures produced by L-701,324 and eliprodil, respectively, was obtained at doses which by themselves did not change the locomotor activity in naive Sprague-Dawley rats. "
10/01/1996 - "The findings that L-701,324 and eliprodil are potent inhibitors of seizure activity induced by cessation of chronic ethanol administration and the fact that they, in contrast to currently available NMDA receptor antagonists, do not produce psychotomimetic and/or sedative effects, suggest that these drugs may represent a new class of therapeutically useful pharmacological agents for the treatment of ethanol withdrawal seizures. "
01/01/2011 - "The anticonvulsant effects of D-cycloserine, which is a partial agonist of the glycine/N-methyl-D-aspartate (NMDA) receptor, and L-701,324, which is a selective and potent antagonist that acts at the glycine site, were studied in electroshock-induced seizures in mice. "
3. Muscle Rigidity
4. Morphine Dependence
5. Epilepsy (Aura)

Related Drugs and Biologics

1. Pentylenetetrazole (Metrazol)
2. Amphetamine (Amfetamine)
3. N-methyl-DL-aspartic acid
4. N-Methyl-D-Aspartate Receptors (NMDA Receptors)
5. Glycine (Aminoacetic Acid)
6. Haloperidol (Haldol)
7. D-Aspartic Acid (D Aspartate)
8. Sarcosine (Methylglycine)
9. Anticonvulsants (Antiepileptic Drugs)
10. MRZ 2-576