WIN 58161

a topoisomerase II inhibitor; structure given in first source; RN given refers to (S)-isomer (WIN 58161)

Also Known As:

10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)(1,4)-benzothiazine-6-carboxylic acid; WIN 58161, (R)-isomer; WIN-58161

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        WIN 58161: 1

Related Diseases

1.	Neoplasms (Cancer) 06/29/1995 - "When studied in tumor-bearing mice, WIN 58161 exhibited a significant antitumor effect against each of five tumors tested, whereas neither toxicity nor antitumor activity was observed with WIN 58161-2. We conclude from these studies that WIN 58161 represents the prototype of a novel chemical class of topoisomerase II inhibitor with potential clinical utility in treating cancer."
2.	Leukemia 06/29/1995 - "At drug concentrations that are cytotoxic to P388 murine leukemia cells, WIN 58161 promoted intracellular DNA single-strand breaks (SSBs) that exhibited the hallmarks of being mediated by topoisomerase. "

Related Drugs and Biologics

1.	Topoisomerase II Inhibitors
2.	DNA (Deoxyribonucleic Acid)