glyceryl 2-arachidonate (2-arachidonoylglycerol)

binds to cannabinoid receptors; structure in first source

Also Known As:

2-arachidonoylglycerol; 2-arachidonyl-glycerol; 2-arachidonoyl-glycerol; 2-arachidonylglycerol; 2-monoarachidonoylglycerol; 5,8,11,14-eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (all-Z)-; 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-

Networked: 260 relevant articles (8 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        glyceryl 2-arachidonate: 260
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        glyceryl 2-arachidonate: 260
  - Endocannabinoids: 3573
    - glyceryl 2-arachidonate: 260
- Glycerides: 109
  - glyceryl 2-arachidonate: 260

Experts

1.	Di Marzo, Vincenzo: 12 articles (01/2021 - 09/2003)
2.	Gokoh, Maiko: 7 articles (12/2006 - 04/2004)
3.	Kishimoto, Seishi: 7 articles (12/2006 - 04/2004)
4.	Oka, Saori: 7 articles (12/2006 - 04/2004)
5.	Sugiura, Takayuki: 7 articles (12/2006 - 04/2004)
6.	Lutz, Beat: 6 articles (01/2021 - 10/2006)
7.	Hillard, Cecilia J: 6 articles (01/2020 - 12/2004)
8.	Muccioli, Giulio G: 6 articles (01/2019 - 02/2008)
9.	Petrosino, Stefania: 6 articles (06/2013 - 09/2005)
10.	Cravatt, Benjamin F: 5 articles (12/2021 - 08/2010)

Related Diseases

1.	Pain (Aches) 01/01/2021 - "Human 2-arachidonoylglycerol (2-AG) is an agonist of endocannabinoid system and acts as an important modulator of many physiological processes such as emotional state and pain sensation. " 01/01/2020 - "[1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone is presented in this report to be a novel, potent, selective, and reversible noncovalent MAGL inhibitor that demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol as well as efficacy in models of neuropathic and inflammatory pain." 02/01/2010 - "Endocannabinoids (ECs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), modulate a number of physiological processes, including pain, appetite and emotional state. " 01/01/2018 - "2-Arachidonoylglycerol (2-AG) is an important endogenous signaling lipid that activates the cannabinoid receptors (CB1 R and CB2 R), thereby regulating a diverse range of physiological processes including anxiety, appetite, inflammation, memory, pain sensation, and nociception. " 09/01/2014 - "Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol."
2.	Infarction (Infarctions) 06/01/2009 - "Pretreatment with 2-arachidonylglycerol and N-arach-idonoylethanolamine-anandamide also reduced infarct size and improved neurological outcome. " 04/01/2005 - "We reported earlier that closed head injury (CHI) in mice causes a sharp elevation of brain 2-arachidonoylglycerol (2-AG) levels, and that exogenous 2-AG reduces brain edema, infarct volume and hippocampal death and improved clinical recovery after CHI. " 04/01/2012 - "In contrast to 16 control patients with normal coronary artery angiogram, the endocannabinoid 2-arachidonoylglycerol level in the infarct-side coronary artery of 23 AMI patients increased significantly, with increased reactive oxygen species and tumor necrosis factor-α levels in both infarct-side coronary artery and radial artery. "
3.	Inflammation (Inflammations) 01/01/2023 - "Unexpectedly, while CB1R desensitization significantly reduces the inhibition produced by exogenous agonists, depolarization-induced suppression of inhibition protocols that promote 2-arachidonoylglycerol (2-AG) synthesis exhibit prolonged CB1R activation after inflammation. " 12/01/2004 - "We also found that the level of 2-arachidonoylglycerol in mouse ear is markedly elevated following treatment with 12-O-tetradecanoylphorbol 13-acetate, which induces acute inflammation. " 08/01/2011 - "In conclusion, increasing 2-arachidonoylglycerol levels resulted in a dramatic reduction of colitis and of the related systemic and central inflammation. " 08/01/2011 - "Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation." 05/06/2005 - "In this study, we investigated possible pathophysiological roles of the CB2 receptor and 2-arachidonoylglycerol in acute inflammation in mouse ear induced by the topical application of 12-O-tetradecanoylphorbol-13-acetate. "
4.	Hyperalgesia 01/01/2023 - "Efficacy of inhibiting 2-arachidonoylglycerol hydrolysis to mitigate periorbital allodynia was then tested using reversal and prevention paradigms. " 08/01/2022 - "Attenuation of allodynia and microglial reactivity by inhibiting the degradation of 2-arachidonoylglycerol following injury to the trigeminal nerve in mice." 11/01/2022 - "Here, we examined the role of 2-arachidonoylglycerol (2-AG)-mediated endocannabinoid (eCB) signaling in the regulation of hyperalgesia associated with alcohol withdrawal in mice. " 04/01/2008 - "Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity." 06/01/2012 - "Our goal in this study was to further characterize this peptide and to clarify the antinociceptive potency of the polyunsaturated fatty acid derivates, 2-arachidonoyl-glycerol (2-AG) and anandamide, by investigating their effects on mechanical allodynia at the spinal level. "
5.	Insulin Resistance 01/01/2017 - "2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes." 03/23/2018 - "In the current study, we investigated the inhibitory effects of GN on hepatic CB1R-mediated insulin resistance and gluconeogenesis in 2-arachidonoylglycerol (AG; an agonist of CB1R)-treated HepG2 cells and in high-fat diet (HFD)-induced obese mice. " 01/01/2017 - "In the overall cohorts, 2-arachidonoylglycerol displayed BMI-independent relationships with dyslipidemia (preMW, MW and men), insulin resistance (MW and men), and hypertension (men), but not with waist circumference. " 01/01/2017 - "Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women." 03/01/2020 - "To date, 2-arachidonoylglycerol (2-AG) derivative endocannabinoids are consistently reported to be elevated in insulin resistance, whereas the N-arachidonoylethanolamine (AEA) endocannabinoid derivatives are elevated in obesity. "

Related Drugs and Biologics

1.	Endocannabinoids
2.	anandamide (arachidonylethanolamide)
3.	Enzymes
4.	fatty-acid amide hydrolase (fatty acid amide hydrolase)
5.	Monoacylglycerol Lipases
6.	palmidrol
7.	JZL 184
8.	Cannabinoids
9.	Cannabinoid Receptors (Cannabinoid Receptor)
10.	Arachidonic Acid (Vitamin F)

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	Length of Stay
3.	Therapeutics
4.	Hemoperfusion
5.	Ligation