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FR 144420

structure in first source

Also Known As:

FR-144420; FR144420; N-(4-ethyl-3-(hydroxyimino)-5-nitro-3-hexen-1-yl)-3-pyridinecarboxamide

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nicotinic Acids: 13
      - FR 144420: 2
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - FR 144420: 2
Organic Chemicals: 133
- Nitro Compounds: 66
  - FR 144420: 2

Experts

1.	Islam, Md Shafiqul: 1 article (04/2003)
2.	Kimura, Masahide: 1 article (04/2003)
3.	Ohkuma, Hiroki: 1 article (04/2003)
4.	Suzuki, Shigeharu: 1 article (04/2003)

Related Diseases

1.	Intracranial Vasospasm 04/01/2003 - "FK409 and FR144420 have potential uses for the treatment and prevention of SAH-induced cerebral vasospasm." 04/01/2003 - "The fungal derived nitric oxide donors, (E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409) and N-[(E)-4-ethyl-3-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl]-3-pyridinecarboxamide (FR144420), were evaluated for the treatment and prevention of cerebral vasospasm induced by subarachnoid hemorrhage (SAH) by an in vitro study using rabbit basilar artery. "
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 04/01/2003 - "The fungal derived nitric oxide donors, (E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409) and N-[(E)-4-ethyl-3-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl]-3-pyridinecarboxamide (FR144420), were evaluated for the treatment and prevention of cerebral vasospasm induced by subarachnoid hemorrhage (SAH) by an in vitro study using rabbit basilar artery. "
3.	Coronary Vasospasm (Coronary Artery Vasospasm) 05/06/1996 - "These data suggest that FR144420 inhibits coronary vasospasm for longer than FK409 does and particularly shows more prolonged antianginal effects than hypotensive effects in the methacholine-induced coronary vasospasm model. " 05/06/1996 - "In the rat methacholine-induced coronary vasospasm model, FR144420 suppressed the elevation of the ST segment dose dependently and significantly at 1.0 mg/kg, i.d. " 05/06/1996 - "(+/-)-N-[(E)-4-ethyl-3-[(Z-hydroxyimino]-5-nitro-3-hexenyl] -3-pyridinecarboxamide (FR144420) and (+/-)-(E)-ethyl-2-[(E)-hydroxyimino] -5-nitro-3-hexenamide (FK409), in two different rat models of coronary vasospasm. " 05/06/1996 - "In the rat vasopressin-induced coronary vasospasm model, FR144420 (32 mg/kg) significantly inhibited the depression of the ST segment both 60 min and 120 min after oral administration, whereas FK409 (32 mg/kg) significantly inhibited this ST depression only 60 min after oral administration. "

Related Drugs and Biologics

1.	Niacinamide (Nicotinamide)
2.	Nitric Oxide Donors
3.	Methacholine Chloride (Methacholine)
4.	Vasopressins (Vasopressin)

Related Therapies and Procedures

1.	Oral Administration