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N-alpha-acetyl-nona-D-arginine amide acetate

inhibits HIV-1 by acting as competitive inhibitor of HIV Tat protein; cxcr4 receptor antagonist; structure in first source

Also Known As:

ALX40 4C; ALX40-4C; N-alpha-acetylnona-D-arginine amide acetate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - N-alpha-acetyl-nona-D-arginine amide acetate: 3

Experts

1.	Baribaud, F: 1 article (04/2001)
2.	Benovic, J L: 1 article (04/2001)
3.	Cameron, W: 1 article (04/2001)
4.	Diaz-Mitoma, F: 1 article (04/2001)
5.	Doms, R W: 1 article (04/2001)
6.	Doranz, B J: 1 article (04/2001)
7.	Filion, L G: 1 article (04/2001)
8.	Orsini, M J: 1 article (04/2001)
9.	Sahai, J: 1 article (04/2001)
10.	Sitar, D S: 1 article (04/2001)

Related Diseases

1.

04/10/2001 - "We also found that ALX40-4C interacts with the second extracellular loop of CXCR4 and inhibits infection exclusively by blocking direct virus-CXCR4 interactions."
10/20/1997 - "Thus, ALX40-4C represents a small-molecule inhibitor of HIV-1 infection that acts directly against a chemokine receptor at the level of Env-mediated membrane fusion."
03/01/2001 - "However, high concentrations of T134, T140, and ALX40-4C (see text for full name) increased the expression of CCR5 and R5 HIV-1 infection, as did stromal cell-derived factor 1 (SDF-1). "

Related Drugs and Biologics

1.	Chemokine CXCL12
2.	Chemokine Receptors
3.	T134 peptide
4.	T140 peptide