cytochrome P-450 CYP1B1 (CYP1B1)

an enzyme that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; inducable by polycyclic aromatic hydrocarbons; amino acid sequence given in first source; GenBank U09540

Also Known As:

Networked: 671 relevant articles (9 outcomes, 136 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gonzalez, Frank J: 15 articles (01/2016 - 02/2003)
2.	Dahiya, Rajvir: 11 articles (04/2015 - 08/2002)
3.	Estes, Anne M: 10 articles (01/2016 - 12/2010)
4.	Malik, Kafait U: 10 articles (01/2016 - 12/2010)
5.	Jennings, Brett L: 9 articles (01/2016 - 12/2010)
6.	Tanaka, Yuichiro: 9 articles (04/2015 - 08/2002)
7.	Mandal, Anil K: 9 articles (01/2011 - 05/2002)
8.	Fang, Xiao R: 8 articles (05/2015 - 12/2010)
9.	Dada, Tanuj: 8 articles (01/2014 - 01/2009)
10.	Dada, Rima: 8 articles (01/2014 - 01/2009)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 09/01/2010 - "Hence, selective inhibition of CYP1B1 is recognized to be beneficial for the prevention of E(2) related breast cancer. " 01/01/2009 - "The results demonstrate that CYP1B1 wild type in combination with COMT heterozygous or their inverse combination offer protection against breast cancer in premenopausal Indian women." 12/01/2012 - "The aim of this study was to investigate if the CYP1B1 protein expression shows covariation with the COX-2 and phosphorylated ERα (p-ERα) in human breast cancer. " 07/01/2010 - "The combined effect of CYP1B1*3 polymorphism and NAT2 slow acetylator genotype contributed to an increased risk for breast cancer in patients in this study (p=0.004)." 01/01/2009 - "The present study was performed to evaluate the associations of CYP1B1 Leu(432)Val and/or COMT Val(158)Met polymorphisms with total, premenopausal and postmenopausal breast cancer risks in Indian women. "
2.	Neoplasms (Cancer) 04/01/2008 - "These results suggest that SA induces apoptotic cell death as well as CYP1B1 inhibition and may thus be beneficial in cancer prevention." 02/01/2010 - "Alterations in translational control during malignant transformation may help to explain the tumor-specific expression of CYP1B1 protein." 05/01/2014 - "By pooling all eligible studies, we found that the CYP1B1 Leu432Val polymorphism was not associated with overall urinary system cancers. " 05/01/2014 - "In this meta-analysis, by searching online databases and references of related reviews, we identified 17 eligible studies to assess the relationship between CYP1B1 Leu432Val polymorphism and urinary system cancers, including 7,783 cancer cases and 7,238 controls. " 01/01/2014 - "To understand the CYP1B1 mediated etiopathology of PCG and pathomechanism of various cancers, it is important to carry out its functional studies. "
3.	Obesity 05/02/2014 - "CYP1B1-humanized mice show higher diet-induced obesity compared with Cyp1b1-null mice, suggesting that human CYP1B1 shows a similar response to HFD as mouse Cyp1b1. " 05/02/2014 - "Disruption of Cyp1b1 in mice results in suppression of high-fat diet (HFD)-induced obesity and an extensive change in hepatic energy regulation despite minimal constitutive expression of CYP1B1 in hepatocytes. " 05/02/2014 - "Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity." 01/01/2015 - "CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice." 05/02/2014 - "Lack of CYP1B1 is correlated with altered lipid metabolism, especially lysophosphatidylcholines, contributing to protection against obesity. "
4.	Hypertension (High Blood Pressure) 05/01/2015 - "The present study was conducted to determine if Cyp1b1 gene disruption ameliorates renal dysfunction and organ damage associated with ANG II-induced hypertension in female mice. " 07/01/2014 - "These data suggest that CYP1B1 protects against Ang II-induced hypertension and associated cardiovascular changes in female mice, most likely mediated by 2-methoxyestradiol-inhibiting oxidative stress and the activity of these signaling molecules. " 04/01/2014 - "CYP1B1 could be a novel target for developing drugs to treat hypertension and its pathogenesis." 04/01/2014 - "These data suggests that increased oxidative stress generated by CYP1B1 contributes to hypertension, increased cytokine production and sympathetic activity, and associated pathophysiological changes in SHR. " 06/01/2015 - "Previously, we showed that Cyp1b1 gene disruption minimizes angiotensin II-induced hypertension and associated pathophysiological changes in male mice. "
5.	Glucose Intolerance 01/01/2015 - "CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice."

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A1 (CYP1A1)
2.	Estrogens (Estrogen)
3.	Berberine
4.	Phytoestrogens (Phytoestrogen)
5.	Lysophosphatidylcholines (Lysophosphatidylcholine)
6.	Cytochrome P-450 Enzyme System (Cytochrome P450)
7.	cytochrome P-450 CYP1B1 (CYP1B1)
8.	Messenger RNA (mRNA)
9.	Cytochrome P-450 CYP1A2 (CYP1A2)
10.	Codon (Codons)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chemoprevention
3.	Immunotherapy
4.	Therapeutics
5.	Cystectomy