kievitone

a naturally-occurring, highly hydroxylated isoflavanoid; inhibits the proliferation of breast cancer cell lines; structure given in first source

Also Known As:

3-(2,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,3-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

Breast Neoplasms (Breast Cancer)

06/15/1995 - "The isoflavonoid kievitone potently inhibited the proliferation of the oestrogen receptor (ER)-positive breast cancer cell lines MCF-7 and T47D and the ER-negative breast cancer cell line SKBR3 (IC50 values 5-18 microM). "
06/15/1995 - "Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein."
06/15/1995 - "Compared with kievitone, genistein was 3-9 fold weaker as an inhibitor of the proliferation of the breast cancer cell lines and of growth factor-stimulated DNA synthesis. "

Related Drugs and Biologics

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)
2.	Genistein
3.	DNA (Deoxyribonucleic Acid)