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BRL 32872

structure given in first source

Also Known As:

BRL-32872; N-(3,4-dimethoxyphenyl)-N-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-4-nitrobenzamide hydrochloride

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Karle, Christoph A: 1 article (01/2002)
2.	Kiehn, Johann: 1 article (01/2002)
3.	Thomas, Dierk: 1 article (01/2002)

Related Diseases

1.	Ischemia 01/01/2002 - "BRL-32872 is very effective in the treatment of ventricular arrhythmias in animal models of cardiac ischemia. " 10/01/1995 - "The antifibrillatory potential of BRL-32872, a novel antiarrhythmic compound with K+ and Ca2+ channel blocking activities, was examined in a minipig model of ischemia-induced arrhythmia. "
2.	Cardiac Arrhythmias (Arrythmia) 10/01/1995 - "The antifibrillatory potential of BRL-32872, a novel antiarrhythmic compound with K+ and Ca2+ channel blocking activities, was examined in a minipig model of ischemia-induced arrhythmia. " 02/01/1996 - "To test this hypothesis, the antiarrhythmic versus proarrhythmic profile of BRL-32872, a novel agent with combined potassium and calcium channel blocking activity, was assessed in two different in vivo models of ventricular arrhythmia. "
3.	Myocardial Ischemia (Ischemic Heart Diseases) 10/01/1995 - "Antifibrillatory effects of BRL-32872 in anesthetized Yucatan minipigs with regional myocardial ischemia."
4.	Torsades de Pointes (Torsade de Pointes) 02/01/1996 - "In a second model, the proarrhythmic potential of BRL-32872 was assessed in anesthetized rabbits sensitized to develop torsades de pointes (TdP). "
5.	Ventricular Fibrillation 10/01/1995 - "The effects of intravenous (i.v.) BRL-32872 (0.3 and 1.0 mg/kg, n = 8), dofetilide (0.3 mg/kg, n = 8), and flecainide (2.0 mg/kg, n = 8), were investigated on the incidence of ventricular fibrillation (VF) during a 20-min occlusion of the left anterior descending coronary artery (LAD). "

Related Drugs and Biologics

1.	Calcium Channels (Calcium Channel)
2.	Verapamil (Calan)
3.	Potassium
4.	Flecainide (Tambocor)
5.	E 4031
6.	dofetilide (Tikosyn)