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4-S-cysteaminylcatechol
an activated form of 4-S-cysteaminylphenol; structure given in first source
Also Known As:
4-S-CAC
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Ethylamines: 5
Mercaptoethylamines
Cysteamine: 1042
4-S-cysteaminylcatechol: 2
Sulfur Compounds: 278
Sulfhydryl Compounds: 4168
Mercaptoethylamines
Cysteamine: 1042
4-S-cysteaminylcatechol: 2
Related Diseases
1.
Melanoma (Melanoma, Malignant)
06/15/1995 - "
4-S-CAC was the most cytotoxic to three lines of melanoma cells in vitro, followed by 2-S-CAH and 3-S-CAC.
"
06/15/1995 - "
4-S-CAC was found to be a better substrate for melanoma tyrosinase than was L-3,4-dihydroxyphenylalanine, the natural catecholic substrate.
"
05/15/1997 - "
In vitro experiments showed that (1) the cytotoxicity of 4-S-CAC was mostly prevented by catalase and superoxide dismutase, (2) BQ was highly cytotoxic to B16 melanoma cells (IC50 being 3.9 microM as compared with 507 microM for 4-S-CAP), (3) BQ was metabolized rapidly to a GSH adduct in melanoma cells, and (4) the same GSH adduct was also formed upon incubation of melanoma cells with 4-S-CAP, the reaction being tyrosinase dependent.
"
2.
Experimental Melanoma
05/15/1997 - "
In vitro experiments showed that (1) the cytotoxicity of 4-S-CAC was mostly prevented by catalase and superoxide dismutase, (2) BQ was highly cytotoxic to B16 melanoma cells (IC50 being 3.9 microM as compared with 507 microM for 4-S-CAP), (3) BQ was metabolized rapidly to a GSH adduct in melanoma cells, and (4) the same GSH adduct was also formed upon incubation of melanoma cells with 4-S-CAP, the reaction being tyrosinase dependent.
"
Related Drugs and Biologics
1.
Monophenol Monooxygenase (Tyrosinase)
2.
Levodopa (L Dopa)
3.
Catalase
4.
superoxide dismutase 2