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RK 682

an ecto-phosphatase inhibitor from soil Streptomyces sp.; no other information available 7/95

Also Known As:

RK-682; RK682

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Phosphoprotein Phosphatases: 1211
        RK 682: 3
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Phosphoprotein Phosphatases: 1211
      - RK 682: 3

Experts

1.	Anai, Satoshi: 1 article (05/2020)
2.	Fujii, Tomomi: 1 article (05/2020)
3.	Fujimoto, Kiyohide: 1 article (05/2020)
4.	Hori, Shunta: 1 article (05/2020)
5.	Konishi, Noboru: 1 article (05/2020)
6.	Miyake, Makito: 1 article (05/2020)
7.	Morizawa, Yosuke: 1 article (05/2020)
8.	Nakai, Yasushi: 1 article (05/2020)
9.	Shimada, Keiji: 1 article (05/2020)
10.	Tanaka, Nobumichi: 1 article (05/2020)

Related Diseases

1.	B-Cell Leukemia (Leukemia, B Cell) 09/18/1995 - "In situ, sodium orthovanadate and RK-682 enhanced the phosphotyrosine level of Ball-1 cells, a human B cell leukemia, but not the phosphoserine/threonine level. "
2.	Poisoning 11/20/2017 - "Twenty-two putative gene clusters with high or moderate similarity to important antibiotic biosynthetic gene clusters were found, including the antitumor agents bafilomycin, epothilone and hedamycin; the antibacterial/antifungal agents clavulanic acid, collismycin A, frontalamides, kanamycin, streptomycin and streptothricin; the protein phosphatase inhibitor RK-682; and the acute iron poisoning medication desferrioxamine B. "
3.	Neoplasms (Cancer) 05/27/2020 - "Using human urothelial cancer cell lines, MGH-U3 and T24, heparanase expression was reduced with siRNA and RK-682, a heparanase inhibitor, to examine changes in cell proliferation activity, induction of apoptosis, invasion ability of cells, and its relationship to autophagy. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 05/27/2020 - "A bladder cancer development mouse model was treated with RK-682 and the bladder tissues were examined using immunohistochemical analysis for Ki-67, E-cadherin, LC3, and CD31 expressions. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Epothilones (Epothilone)
3.	Clavulanic Acid (Potassium Clavulanate)
4.	Phosphotyrosine
5.	Cadherins (E-Cadherin)
6.	Vanadates (Orthovanadate)
7.	Threonine (L-Threonine)
8.	Streptothricins
9.	Streptomycin (Streptomycin Sulfate)
10.	Sodium