3-phenylpropyl isothiocyanate

02/01/1996 - "The results in the present study thus clearly indicate that PPITC has an effective chemopreventive action on BOP-induced lung tumorigenesis in hamsters."
12/01/1998 - "To determine the chemopreventive efficacy of PPITC on NNN-induced esophageal tumorigenesis, rats were fed AIN-76A diets containing 0, 1.0 or 2.5 micromol/g PPITC and were given untreated drinking water or drinking water containing 5 p.p.m. "
12/01/1998 - "Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate."
02/01/1996 - "Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine."
05/01/1995 - "PPITC clearly had a stronger inhibitory effect on NMBA tumorigenesis than did PEITC. "

12/01/1998 - "These results demonstrate the remarkable chemopreventive efficacy of PPITC in the NNN-induced esophageal tumor model."
12/01/1998 - "The two dietary concentrations of PPITC reduced the incidence and multiplicity of NNN-induced esophageal tumors by >95%. "
02/01/1996 - "The data for multiplicity of lung tumors dramatically illustrated the inhibitory effects of PPITC, and there were also statistically significant differences in the chemopreventive effect between 100 microM and 10 microM PPITC treatments. "
05/01/1995 - "Tumor multiplicities were inhibited by 83-100% by PEITC or PPITC at all dietary concentrations tested. "
05/01/1995 - "Tumor incidences in rats treated with 2.5 and 1.0 mumol PEITC/g diet, and with all three dietary concentrations of PPITC were inhibited by 60-100% compared to controls. "

02/01/1996 - "Animals in groups 4-6, each consisting of 10 hamsters, were given 100 microM or 10microM of PPITC alone, or non-treated, thus being available as matched negative controls to groups 1-3. At termination (experimental week 51 after the first BOP injection), the incidences of lung adenomas and/or adenocarcinomas were significantly decreased in groups 1 and 2 as compared to the group 3 value (p<0.01). "

02/01/1996 - "Animals in groups 4-6, each consisting of 10 hamsters, were given 100 microM or 10microM of PPITC alone, or non-treated, thus being available as matched negative controls to groups 1-3. At termination (experimental week 51 after the first BOP injection), the incidences of lung adenomas and/or adenocarcinomas were significantly decreased in groups 1 and 2 as compared to the group 3 value (p<0.01). "