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tartrate-resistant acid phosphatase (TSAP)

Subscribe to New Research on tartrate-resistant acid phosphatase

used as a marker for leukemic hairy cells, for bone resorption and osteoclastic differentiation; ; amino acid sequence has been determined; see also purple acid phosphatase; RefSeq NM_001611, NM_019144 (rat), NM_007388 (mouse)

Also Known As:

TSAP; ACP5 protein, Sus scrofa; ACP5 protein, human; AcPase V; Acp5 protein, mouse; Acp5 protein, rat; TRACP 5b, human; TRAP protein, human; TRAP type 5 AcPase; TRAcP; Tartrate-resistant acid phosphatase type 5; Tartrate-resistant acid phosphatase type 5 protein, Sus scrofa; Trap protein, mouse; Uteroferrin protein, Sus scrofa; acid phosphatase 5, tartrate resistant protein, human; acid phosphatase 5, tartrate resistant protein, mouse; acid phosphatase 5, tartrate resistant protein, rat; acid phosphatase V; tartrate-sensitive acid phosphatase; type 5 acid phosphatase; uteroferrin

Networked: 745 relevant articles (10 outcomes, 61 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Janckila, Anthony J: 23 articles (06/2014 - 06/2002)
2.	Chao, Tsu-Yi: 17 articles (12/2015 - 05/2003)
3.	Yam, Lung T: 17 articles (09/2011 - 06/2002)
4.	Halleen, Jussi M: 13 articles (11/2013 - 06/2002)
5.	Terpos, Evangelos: 12 articles (01/2014 - 01/2003)
6.	Andersson, Göran: 10 articles (11/2015 - 09/2004)
7.	Wu, Yi-Ying: 9 articles (01/2015 - 04/2008)
8.	Väänänen, H Kalervo: 8 articles (05/2008 - 10/2003)
9.	Lee, Su-Huei: 7 articles (12/2015 - 07/2004)
10.	Ku, Chih-Hung: 7 articles (05/2011 - 01/2005)

Related Diseases

1.	Bone Resorption 01/01/2014 - "In our study, gene knockout mice, RNA interference, western blot, quantitative real-time PCR, tartrate-resistant acid phosphatase (TRAP) staining, pit formation assay, histomorphometry and measurement of serum parameters were employed to investigate the role of TRPV6 in bone homeostasis, osteoclastogenesis and bone resorption. " 01/01/2010 - "Tartrate-resistant acid phosphatase 5b, a good bone resorption marker, was significantly decreased at week 2 of the study. " 01/01/2001 - "After 12 weeks histologic studies of treated animals revealed that osteoclasts were positive for tartrate-resistant acid phosphatase but showed markedly abnormal ultrastructure which prevented successful bone resorption. " 07/31/1992 - "This provides opportunities to develop the use of Type 5 acid phosphatase as a reporter of pathophysiological events and an essential, though not sufficient, role in bone resorption by osteoclasts has been established by such studies." 07/01/2015 - "In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2010 - "We tested the hypothesis that baseline serum TRACP 5b activity and its interval change are potential prognostic markers of survival in BC patients with bone metastasis. " 05/01/2009 - "We also found an unusually low TRACP-5b/RANKL ratio for patients who have or later developed metastasis. " 11/01/2006 - "Of the three novel markers tested, only TRACP 5b proved to be predictive of survival in PC with bone metastases. " 07/01/2006 - "The combination of TRACP with ICTP did not significantly improve the detection of bone metastases over tALP." 07/01/2006 - "Serum TRACP 5b, ICTP and tALP exhibited equal performances in the detection of bone metastases. "
3.	Breast Neoplasms (Breast Cancer) 12/01/2015 - "Association of Tartrate-Resistant Acid Phosphatase-Expressed Macrophages and Metastatic Breast Cancer Progression." 11/15/2015 - "The small chemical enzyme inhibitor 5-phenylnicotinic acid/CD13 inhibits cell migration and invasion of tartrate-resistant acid phosphatase/ACP5-overexpressing MDA-MB-231 breast cancer cells." 01/01/2011 - "The TRAcP 5b concentration was significantly higher in breast cancer patients compared to healthy probands. " 02/01/2007 - "Human breast cancer cell lines and tissues express tartrate-resistant acid phosphatase (TRAP)." 03/01/2003 - "These results suggest that serum TRACP 5b activity may be a useful marker for the early detection of the spreading of breast cancer cells to bone."
4.	Neoplasms (Cancer) 01/01/2014 - "Osteoclasts in tumor sections were also stained for tartrate-resistant acid phosphatase (TRAP). " 01/01/2011 - "In vitro differentiation of SPARC KO osteoclasts indicated accelerated progenitor expansion and formation of tartrate-resistant acid phosphatase-positive osteoclast-like cells with increased resorptive capacity, a mechanism resulting in enhanced tumor-induced bone loss in vivo. " 10/01/2009 - "The tumors were resected, and stained with TUNEL stain, tartrate-resistant acid phosphatase (TRAP) stain to detect tumor-associated macrophages, and immunohistochemical stains for CD4 and CD8. " 01/01/2009 - "Coculture of tumor cells with bone marrow significantly increased activation of bone marrow-derived osteoclasts as assessed by tartrate-resistant acid phosphatase staining (156 +/- 10.8 osteoclasts per well) compared to bone marrow culture alone (91.67 +/- 4.7, P = .005). " 12/01/2008 - "In conclusion, tumor-infiltrating osteoclasts are frequently found in OS and increased serum TRACP 5b levels and the presence of active osteoclast at primary sites were positively associated with tumor aggressiveness."
5.	Hairy Cell Leukemia 03/01/2005 - "The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia." 06/01/2004 - "Tartrate resistant acid phosphatase (TRAP) staining and scanning electron microscopy of peripheral blood lymphocytes indicated hairy cell leukemia. " 11/01/2001 - "TRACP 5b is considered to be a marker of the osteoclasts and 5a is found in Gaucher's cells, or in the leukocytes of patients with hairy cell leukemia." 09/01/1997 - "The demonstration of tartrate-resistant acid phosphatase (TRAP) activity has long been a cornerstone in the diagnosis of hairy cell leukemia (HCL). " 12/01/1993 - "Tartrate-resistant acid phosphatase (TRAP) became known as the characteristic, albeit not specific, marker enzyme for hairy cell leukemia (HCL). "

Related Drugs and Biologics

1.	Osteocalcin
2.	Alkaline Phosphatase
3.	denosumab
4.	Proguanil (Paludrine)
5.	tartrate-resistant acid phosphatase (TSAP)
6.	Biological Markers (Surrogate Marker)
7.	Hydroxyproline (4 Hydroxyproline)
8.	ruberythric acid (AlP)
9.	Collagen Type I (Type I Collagen)
10.	Calcium

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Arthroplasty
3.	Aftercare (After-Treatment)
4.	Transplants (Transplant)
5.	Tooth Movement