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sodium-hydrogen exchanger regulatory factor

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a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na+-H+ exchanger; 358 amino acids, MW 55 kDa; partial amino acid sequence given in first source

Also Known As:

E3KARP protein, human; E3karp protein, mouse; EBP-50 protein, mouse; EBP50 protein, human; ERM-binding phosphoprotein 50, human; NHE-RF protein; NHERF; NHERF-1 protein, human; NHERF-1 protein, mouse; NHERF-2 protein, human; NHERF-2 protein, mouse; NHERF1 protein, zebrafish; NHERF2 protein, human; NHERF4 protein, mouse; Na+-H+ exchanger-regulatory factor; SLC9A3R1 protein, human; SLC9A3R2 protein, human; Slc9a3r1 protein, mouse; Slc9a3r1 protein, rat; Slc9a3r2 protein, mouse; TKA-1 protein, human; Tka-1 protein, mouse; sodium-hydrogen exchanger regulatory factor 1; sodium-hydrogen exchanger regulatory factor 2; sodium-hydrogen exchanger regulatory factor 2 protein, human; sodium-hydrogen exchanger regulatory factor 2 protein, mouse; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1, human; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1, mouse; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1, rat; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 protein, human; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 protein, mouse; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 protein, human

Networked: 23 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Weinman, Edward J: 5 articles (10/2015 - 12/2005)
2.	Pan, Yong: 3 articles (01/2008 - 11/2004)
3.	Dai, Jia Le: 3 articles (01/2008 - 11/2004)
4.	Paradiso, Angelo: 2 articles (09/2015 - 11/2011)
5.	Tommasi, Stefania: 2 articles (09/2015 - 11/2011)
6.	Simone, Giovanni: 2 articles (09/2015 - 11/2011)
7.	Donowitz, Mark: 2 articles (04/2011 - 02/2009)
8.	Zachos, Nicholas C: 2 articles (04/2011 - 02/2009)
9.	Cunningham, Rochelle: 2 articles (05/2007 - 04/2006)
10.	Shenolikar, Shirish: 2 articles (05/2007 - 04/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2007 - "Our data suggest that this single molecule can modulate NHERF localization and, independently, act as a key orchestrator of apical cell morphology, thereby lending mechanistic insights into its multiple roles as a polarity regulator, tumor progression marker, and anti-adhesin." 11/01/2011 - "The familial cancers were immunonegative for membranous Na+/H+ exchanger regulatory factor 1 expression compared with sporadic cancers (P = .001); notably, vascular endothelial growth factor receptor 1 staining correlated with cytoplasmic Na+/H+ exchanger regulatory factor 1 expression in familial tumors (P = .009). " 07/01/2015 - "Mounting evidence strongly suggests that NHERF proteins may have clinically significant roles in pharmacokinetics and pharmacodynamics of several pharmacologically active compounds and may affect drug action in cancer and chronic kidney disease. " 10/01/2001 - "NHERF overexpression in human breast cancers and mutations in NHERF targets, such as CFTR and merlin, the product of Neurofibromatosis NF2 tumor suppressor gene, that impair NHERF binding suggest that aberrant NHERF function contributes to human disease." 02/22/2006 - "PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling."
2.	Breast Neoplasms (Breast Cancer) 01/01/2006 - "Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)." 11/11/2004 - "We found intragenic mutation of the NHERF gene accompanied by loss of heterzygosity (LOH) in approximately 3% (3/85) of breast cancer cell lines and primary breast tumors. " 11/11/2004 - "Primary breast tumors with LOH at the NHERF locus had clinical presentations of higher aggressiveness, indicating that deregulated NHERF signaling may be associated with disease progression. " 10/11/2013 - "Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling." 11/01/2011 - "We hypothesize that the evaluation of human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 could be clinically useful to identify familial breast tumors and to select patients candidate to breast cancer susceptibility genes 1/2 gene sequencing."
3.	Cystic Fibrosis (Mucoviscidosis) 02/20/2004 - "Characterization of the basis and consequences of NHERF association with ROMK reveals a PDZ interaction-dependent trafficking process and a coupling mechanism for linking ROMK to a channel modifier protein, the cystic fibrosis transmembrane regulator (CFTR). " 01/01/2011 - "β1, β2, and β3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis." 12/09/2005 - "Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis cells."
4.	Carcinoma (Carcinomatosis) 01/01/2008 - "The gene encoding Na+/H+ exchanger regulatory factor 1 (NHERF1) is a putative tumor suppressor gene that harbors frequent loss of heterozygosity (LOH) and intragenic mutations in breast carcinoma. " 11/11/2004 - "Taken together, the results indicated NHERF to be a candidate tumor suppressor gene in human breast carcinoma that may be interconnected to the SYK and MERLIN suppressors." 11/01/2011 - "Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulatory factor 1 in 187 microarrayed breast carcinomas from 94 familial and 93 sporadic breast cancer patients by immunohistochemical staining. "
5.	Infection 04/01/2011 - "Stable infection of Caco-2/bbe cells by NHERF1 or NHERF2 Lenti-shRNA significantly and specifically reduced NHERF protein expression by >80%. " 05/01/2007 - "Infection of NHERF-1(-/-) cells with adenovirus-green fluorescence protein-NHERF-1 resulted in significantly higher rates of uric acid transport (15.4 +/- 1.1 pmol/microg protein per 30 min) compared with null cells that were infected with control adenovirus-green fluorescence protein (7.9 +/- 0.3) and restoration of the inhibitory effect of para-aminohippurate (% inhibition 34 +/- 4%). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	sodium-hydrogen exchanger regulatory factor
3.	Neurofibromin 2 (Merlin)
4.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
5.	Epidermal Growth Factor Receptor (EGF Receptor)
6.	beta Catenin
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)
9.	Small Interfering RNA (siRNA)
10.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)