L 695256

bind to penicillin-binding protein 2A; structure in first source

Also Known As:

2-(7-(1-methylimidazolium-3-yl)methyl-9-fluorenone-3-yl)-6-(1-hydroxyethyl)carbapen-2-em-3-carboxylate; L 695,256; L-695,256; L-695256

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

1.	Infections 02/01/1995 - "Compounds such as L-695,256 that are bound by PBP 2a with a high degree of affinity are likely to be extremely effective in the treatment of infections caused by methicillin-resistant staphylococci."
2.	Endocarditis 02/01/1995 - "Growth of cells of each of two homogeneously resistant strains, COL and 76, was completely inhibited by 4 micrograms of L-695,256 per ml, whereas growth was inhibited by 100 micrograms or more of penicillin or imipenem per ml. The efficacies of L-695,256 (10 mg/kg given three times daily [t.i.d.]), imipenem (37.5 mg/kg t.i.d.), penicillin (300,000 units/kg t.i.d.), and vancomycin (25 mg/kg given twice daily) were compared in the rabbit model of aortic valve endocarditis established with these homogeneous strains. "