Leishmania LACK antigen

LACK - Leishmania homolog of receptors for Activated C Kinase; highly conserved among Leishmania species; amino acid sequence given in first source; RN refers to L. major

Also Known As:

LACK antigen, Leishmania; 36-kDa antigen, Leishmania; antigen LACK, L. chagas; antigen LACK, Leishmania; antigen LACK, Leishmania chagas

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Esteban, Mariano: 2 articles (08/2015 - 08/2005)
2.	Di Pilato, Mauro: 1 article (08/2015)
3.	Mejías-Pérez, Ernesto: 1 article (08/2015)
4.	Sorzano, Carlos Oscar S: 1 article (08/2015)
5.	Sánchez-Sampedro, Lucas: 1 article (08/2015)
6.	Dondji, Blaise: 1 article (08/2005)
7.	Goldsmith-Pestana, Karen: 1 article (08/2005)
8.	McMahon-Pratt, Diane: 1 article (08/2005)
9.	Pérez-Jimenez, Eva: 1 article (08/2005)
10.	Coffman, Robert L: 1 article (02/2002)

Related Diseases

1.	Infections 02/01/1998 - "Recent reports have suggested that after infection of BALB/c mice with Leishmania major, CD4+ T cells responding to a single antigen, LACK (Leishmania homologue of receptors for activated C kinase), drive the differentiation of other responding T cells to the Th2 phenotype and so allow lesion development to occur. " 08/01/2005 - "This study reports the efficacy of a heterologous prime-boost vaccination using DNA and vaccinia viruses (Western Reserve [WR] virus and modified [attenuated] vaccinia virus Ankara [MVA]) expressing the LACK antigen (Leishmania homologue of receptors for activated C kinase) and an intradermal murine infection model employing Leishmania infantum. "
2.	Vaccinia 08/01/2015 - "We generated several recombinant VACVs based on the attenuated modified vaccinia Ankara (MVA) strain, which express GFP or the Leishmania LACK antigen under the control of an optimized promoter, using different spacer lengths. "
3.	Inflammation (Inflammations) 02/01/2002 - "Mice sensitized for a Th2 response to Leishmania LACK antigen developed allergic airway inflammation upon exposure to LACK aerosol. "

Related Drugs and Biologics

1.	Receptors for Activated C Kinase
2.	DNA (Deoxyribonucleic Acid)
3.	Aerosols