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aurora kinase (aurora A kinase)

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highly conserved in eukaryotes and involved in many processes during cell division; Aurora A regulates centrosome function during M phase; Aurora-B plays roles in spindle dynamics, chromosome condensation, and cytokinesis

Also Known As:

aurora A kinase; Serine/threonine-protein kinase 13; aurora B kinase; serine/threonine protein kinase 12; AIK3 protein kinase; AURKC protein, human; AURORA2 protein; Aie1 protein, mouse; Aurkc protein, mouse; Aurora/Ipl1-related kinase 3; BTAK protein; Breast-tumor-amplified kinase; STK13 protein, human; STK15 kinase; Stk13 protein, mouse; aur kinase; aurora kinase A; aurora kinase B; aurora kinase C; aurora kinase C protein, human; aurora kinase C protein, mouse; aurora kinases; aurora-A kinase; aurora-Ipl1-related protein kinase; aurora-related kinase 2; auroraA kinase; serine/threonine protein kinase 15

Networked: 684 relevant articles (34 outcomes, 113 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        aurora kinase: 684

Experts

1.	Sen, Subrata: 16 articles (04/2014 - 03/2003)
2.	Ecsedy, Jeffrey A: 12 articles (12/2015 - 03/2007)
3.	Ecsedy, Jeffrey: 10 articles (12/2013 - 11/2008)
4.	Liu, Quentin: 9 articles (01/2015 - 03/2008)
5.	El-Rifai, Wael: 9 articles (01/2015 - 04/2008)
6.	Katayama, Hiroshi: 9 articles (02/2012 - 12/2003)
7.	Li, Yan: 8 articles (07/2015 - 08/2008)
8.	Coumar, Mohane Selvaraj: 8 articles (01/2015 - 03/2009)
9.	Fingert, Howard: 8 articles (12/2014 - 10/2010)
10.	Moll, Jürgen: 8 articles (09/2012 - 09/2007)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2012 - "Aurora Kinase (AK) based therapy targeting AK-A & B is effective against some cancers. " 04/01/2011 - "In conclusion, our data demonstrated that Aurora kinase inhibition is effective in reducing cell growth and inducing apoptosis of ATC in vitro and tumor growth and vascularity in vivo. " 01/01/2010 - "Therefore, Aurora kinase inhibitors should be useful in the treatment of cancers. " 10/23/2008 - "PTTG1 knockdown is therefore a potential approach to improve the efficacy of tumor Aurora kinase inhibitors." 05/15/2013 - "NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors."
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2013 - "Targeting epigenetics with the HDAC inhibitor, in combination with Aurora kinase inhibitors, holds promise for more effective therapy of ovarian cancer." 09/01/2008 - "The role of Aurora kinase inhibition in ovarian cancer merits further investigation in clinical trials." 01/01/2008 - "We show that inhibition of the Aurora kinases prevents phosphorylation of a mitotic marker and demonstrate a dose-dependent increase of apoptosis in treated ovarian cancer cells. " 07/15/2007 - "Aurora-A kinase is overexpressed by a substantial proportion of ovarian cancers and is associated with centrosome amplification and poor survival. " 07/15/2007 - "Aurora-A kinase expression was assessed by Western blot (cell lines) or immunohistochemistry (high-grade epithelial ovarian cancers), and clinical variables were collected by retrospective chart review. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/01/2007 - "A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia." 03/01/2010 - "In this study, we report the effects of AZD1152-HQPA, a highly selective inhibitor of aurora-B kinase, in acute myeloid leukemia (AML) cell lines and primary samples. " 12/01/2013 - "We previously showed that Aurora kinase A (AURKA) is aberrantly expressed in acute myelogenous leukemia (AML) cells when compared to bone marrow mononuclear cells isolated from healthy volunteers. " 12/01/2013 - "CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express Aurora kinase A." 03/01/2010 - "The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells."
4.	Leukemia 06/01/2007 - "Taken together, inhibition of Aurora kinases may be a promising treatment strategy for individuals with leukemia." 01/29/2015 - "This review will describe the functions of each Aurora kinase, summarize their involvement in leukemia and discuss inhibitor development and efficacy in leukemia clinical trials. " 01/29/2015 - "Several early studies found that Aurora kinases are amplified and overexpressed at the transcript and protein level in various malignancies, including several types of leukemia. " 01/01/2014 - "A comparative analysis of these agents in cytotoxicity and target modulation analyses against a panel of leukemia cells provides novel insights into the unique mechanisms and codependent activity pathways involved in targeting Aurora kinases, constituting a distinctive preclinical experimental framework to identify appropriate agents and combinations in future clinical studies. " 07/01/2012 - "Aurora kinase inhibitors are in early clinical trials for the treatment of leukemia. "
5.	Breast Neoplasms (Breast Cancer) 08/01/2015 - "To the best of our knowledge, this is the first study to show that Aurora kinases are key molecules in PKC-induced invasion in breast cancer cells." 08/01/2015 - "However, few studies have assessed the effect of Aurora kinases in breast cancer. " 05/01/2015 - "p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer." 01/01/2015 - "The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells." 09/15/2014 - "Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells."

Related Drugs and Biologics

1.	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate
2.	Phosphotransferases (Kinase)
3.	Tamoxifen
4.	VX680
5.	MLN 8237
6.	ENMD 2076
7.	Histones (Histone)
8.	Proteins (Proteins, Gene)
9.	4- (4- (N- benzoylamino)anilino)- 6- methoxy- 7- (3- (1- morpholino)propoxy)quinazoline
10.	imatinib (Gleevec)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Immunotherapy
5.	Therapeutics