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checkpoint kinase 2

Subscribe to New Research on checkpoint kinase 2

cds - checking DNA synthesis; a key component of the DNA replication-monitoring S/G2 checkpoint system; homologous to SPK1 of S. cerevisiae; RefSeq NM_145862 (human); NM_016681 (mouse); NM_053677 (rat)

Also Known As:

CHEK2 protein, human; CHK2 checkpoint homolog (S. pombe) protein, human; CHK2 checkpoint homolog (S. pombe) protein, mouse; CHK2 protein, human; Cds1 kinase; Cds1 protein, S pombe; Cds1 protein, Xenopus; Chek2 protein, mouse; Chek2 protein, rat; Chk2 protein kinase; Chk2 protein, S pombe; Chk2 protein, mouse; Chk2 protein, rat; RAD53 protein, human; Rad53 protein, rat; SPCC18B5.11c protein, S pombe; cds1 checkpoint kinase, S pombe; hCds1 protein, human; protein kinase Cds1, Xenopus; protein kinase Chk2, rat; serine-threonine-protein kinase Chk2

Networked: 101 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        checkpoint kinase 2: 101

Experts

1.	Narod, Steven A: 4 articles (08/2015 - 02/2007)
2.	Chou, Wen-Cheng: 3 articles (08/2015 - 02/2006)
3.	Cybulski, Cezary: 3 articles (08/2015 - 02/2007)
4.	Shen, Chen-Yang: 3 articles (08/2015 - 02/2006)
5.	Wokołorczyk, Dominika: 3 articles (08/2015 - 02/2007)
6.	Lubiński, Jan: 3 articles (08/2015 - 02/2007)
7.	Wang, Ying: 3 articles (08/2014 - 01/2012)
8.	Jobson, Andrew G: 3 articles (12/2011 - 01/2009)
9.	Waugh, David S: 3 articles (12/2011 - 01/2009)
10.	Pommier, Yves: 3 articles (12/2011 - 01/2009)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "The cell-cycle checkpoint kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects has been associated with increased risk for breast cancer. " 01/01/2014 - "Immunoblotting showed DCP-induced activation of DNA damage pathways, including double-phosphorylated checkpoint kinase 2 (CHK2) and breast cancer 1 (BRCA1) and triple-phosphorylated p53, compared to controls. " 01/01/2012 - "The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of breast cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice. " 01/01/2011 - "Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. " 12/01/2010 - "CHK2 (checkpoint kinase 2) and BRCA1 (breast cancer early-onset 1) are tumour-suppressor genes that have been implicated previously in the DNA damage response. "
2.	Ataxia Telangiectasia (Louis Bar Syndrome) 08/01/2015 - "Base lesions, which are structurally simple and predominantly fixed by base excision repair (BER), can trigger the ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 (Chk2) pathway, a DDR component. " 01/01/2015 - "This phenotype correlated with a rapid and long-lasting ataxia telangiectasia-mutated (ATM) activation and phosphorylation of checkpoint kinase 2 (CHK2). " 08/01/2014 - "These actions were associated with activation of ataxia-telangiectasia-mutated/checkpoint kinase 2 pathway. " 01/01/2014 - "Ataxia telangiectasia mutated (ATM), checkpoint kinase 2 (Chk2), and p53 expressions were examined by immunohistochemistry using tissue microarray. " 12/01/2010 - "When treated with GA, phosphorylated Cdc25C can be activated by ataxia telangiectasia-mutated checkpoint kinase 2 (Chk2). "
3.	Neoplasms (Cancer) 11/01/2014 - "The aim of the current study is to explore the expression and phosphorylation of checkpoint kinase 2 (Chk2) and TP53, which are key molecules in DDR, and their clinicopathological correlation in the appendiceal tumors. " 08/01/2015 - "Mutations in the cell cycle checkpoint kinase 2 (CHEK2) tumor suppressor gene are associated with multi-organ cancer susceptibility including cancers of the breast and prostate. " 01/01/2015 - "Downregulation of a new miR-17/20 target, checkpoint kinase 2 (Chek2), increases the recruitment of HuR to c-MYC transcripts, resulting in the inhibition of c-MYC translation and thus interfering with in vivo tumor growth. " 01/01/2013 - "MOF negatively regulates Drosophila checkpoint kinase 2 tumor suppressor homologue. " 12/01/2011 - "Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy."
4.	Prostatic Neoplasms (Prostate Cancer) 12/01/2015 - "A high-throughput RNAi screen to identify signaling pathways regulating prostate cancer cell growth led to our discovery that checkpoint kinase 2 (CHK2) knockdown dramatically increased prostate cancer growth and hypersensitized cells to low androgen levels. " 12/01/2015 - "Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth." 05/01/2007 - "Previous studies have indicated that d,l-sulforaphane (SFN), a synthetic cancer chemopreventive analogue of cruciferous vegetable-derived isomer (-)-1-isothiocyanato-(4R)-(methylsulfinyl)-butane, activates a checkpoint kinase 2 (Chk2)-dependent G(2)-M phase cell cycle arrest in p53-deficient human prostate cancer cells. " 08/05/2005 - "The lack of a role of checkpoint kinase 2 in diallyl trisulfide-induced phosphorylation of Cdc25C or G(2)-M phase cell cycle arrest was confirmed using HCT-15 cells stably transfected with phosphorylation-deficient mutant (T68A mutant) of checkpoint kinase 2. In conclusion, the results of the present study suggest existence of a checkpoint kinase 1-dependent mechanism for diallyl trisulfide-induced mitotic arrest in human prostate cancer cells."
5.	Carcinoma (Carcinomatosis) 09/01/2007 - "Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma." 11/01/2008 - "We studied normal mucosa, low-grade dysplasia (LGD) and high-grade dysplasia (HGD) and invasive carcinoma (IC) in matched human colon specimens by evaluating p-ataxia telangiectasia mutated (ATM), p-checkpoint kinase 2 (Chk2), c-H2AX, TRF1 and TRF2 expressions by immunohistochemistry. " 04/01/2006 - "Expression of checkpoint kinase 2 in breast carcinomas: correlation with key regulators of tumor cell proliferation, angiogenesis, and survival." 06/01/2008 - "In the present study we explored a relationship between H2AX phosphorylation and activation of checkpoint kinase 2 (Chk2) in human lung carcinoma A549 cells treated with TPT or with MXT. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Histones (Histone)
3.	Caspase 8 (Caspase-8)
4.	Proteins (Proteins, Gene)
5.	Caspase 3 (Caspase-3)
6.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
7.	Cyclin-Dependent Kinase Inhibitor p16
8.	Cyclin D1
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Caspase 9

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Heterologous Transplantation (Xenotransplantation)