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2- amino- 5,6- dihydro- 6- methyl- 4H- 1,3- thiazine

a selective inhibitor of nitric oxide synthase; structure given in first source

Also Known As:

2-ADHMT

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazines: 3
    - 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine: 4

Experts

1.	Nagatani, Yoshinori: 1 article (03/2009)
2.	Ono, Hideki: 1 article (03/2009)
3.	Saitoh, Kazuya: 1 article (03/2009)
4.	Takasu, Keiko: 1 article (03/2009)
5.	Tanabe, Mitsuo: 1 article (03/2009)
6.	Hirano, Hirofumi: 1 article (01/2003)
7.	Kuratsu, Jun-Ichi: 1 article (01/2003)
8.	Nomoto, Masahiro: 1 article (01/2003)
9.	Oyoshi, Tatsuki: 1 article (01/2003)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 03/01/2009 - "Intrathecal injection of the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME), the highly selective neuronal NOS (nNOS) inhibitor N(omega)-propyl-l-arginine and the potent selective inducible NOS (iNOS) inhibitor 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride (AMT) exerted dose-dependent analgesic effects on thermal and mechanical hypersensitivity, which were assessed by the plantar and von Frey tests, respectively, suggesting that both nNOS and iNOS participate in producing NO to maintain neuropathic pain. "
2.	Neoplasms (Cancer) 11/15/1999 - "Aminoguanidine (AG), 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), NG-monomethyl-L-arginine (L-NMMA), and Nomega-nitro-L-arginine (L-NNA) inhibited NOS activity in tumor tissues by 18, 14, 11 and 13%, respectively. "
3.	Hypertension (High Blood Pressure) 01/01/1999 - "To determine the role of inducible NOS (NOS II) in salt-induced hypertension, we treated Dahl salt-resistant (DR) rats with the selective NOS II inhibitor 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) for 12 days. "
4.	Hypersensitivity (Allergy) 03/01/2009 - "Intrathecal injection of the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME), the highly selective neuronal NOS (nNOS) inhibitor N(omega)-propyl-l-arginine and the potent selective inducible NOS (iNOS) inhibitor 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride (AMT) exerted dose-dependent analgesic effects on thermal and mechanical hypersensitivity, which were assessed by the plantar and von Frey tests, respectively, suggesting that both nNOS and iNOS participate in producing NO to maintain neuropathic pain. "
5.	Glioma (Gliomas) 01/01/2003 - "NO production was also significantly suppressed in the glioma group, but not the control group, by intraperitoneal injection of 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), a selective inhibitor of inducible NOS (iNOS). "

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	NG-Nitroarginine Methyl Ester (L-NAME)
3.	omega-N-Methylarginine (NG Monomethyl L Arginine)
4.	Salts
5.	Arginine (L-Arginine)
6.	Analgesics (Analgesic Drugs)
7.	N(omega)-propylarginine
8.	pimagedine (aminoguanidine)

Related Therapies and Procedures

1.	Spinal Injections
2.	Intraperitoneal Injections