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MS 430

a neurotrophic pyrimidine derivative; structure given in first source

Also Known As:

2-piperidino-5,6-dihydro-7-methyl-6-oxo(7H)pyrrolo(2,3-d)pyrimidine maleate; MS-430

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - MS 430: 3

Experts

1.	Awaya, A: 1 article (02/2001)
2.	Honma, Y: 1 article (02/2001)
3.	Ishii, Y: 1 article (02/2001)
4.	Kakegawa, T: 1 article (02/2001)
5.	Kasukabe, T: 1 article (02/2001)
6.	Okabe-Kado, J: 1 article (02/2001)
7.	Yamamoto-Yamaguchi, Y: 1 article (02/2001)

Related Diseases

1.	Crush Injuries 06/01/1995 - "Therefore, we studied the effect of MS-430 on regeneration of the myelinated fibers of the peroneal and sural nerve of Sprague-Dawley rats after crush injury in two tests, intraperitoneally administered daily 1.0 mg/kg (test 1, n = 7) and 7.5 mg/kg (test 2, n = 8) of MS-430, respectively. " 06/01/1995 - "[The effect of MS-430, a synthetized pyrimidine compound, on regeneration of nerve fibers of rats after crush injury--a morphometric study]."
2.	Ventricular Tachycardia 12/01/1986 - "The QT-interval in the surface electrocardiogram (usually lead II) and the effective refractory period of the right ventricle (ERP-V) were investigated in 16 patients with documented supraventricular tachycardia (SVT) and in 18 patients with documented ventricular tachycardia (VT) during basic pacing (QT1) and programmed stimulation of the right ventricular apex (QT2) (single-test stimulation at 3 different rates, BCL: 600 ms, 500 ms, 430 ms). "
3.	Supraventricular Tachycardia 12/01/1986 - "The QT-interval in the surface electrocardiogram (usually lead II) and the effective refractory period of the right ventricle (ERP-V) were investigated in 16 patients with documented supraventricular tachycardia (SVT) and in 18 patients with documented ventricular tachycardia (VT) during basic pacing (QT1) and programmed stimulation of the right ventricular apex (QT2) (single-test stimulation at 3 different rates, BCL: 600 ms, 500 ms, 430 ms). "
4.	Leukemia 02/01/2001 - "MS-430 potently induces differentiation of some myelomonocytic leukemia cells. " 02/01/2001 - "MS-430 also induced monocytic differentiation of THP-1, P39/Tsu, and P31/Fuj leukemia cells, but did not affect erythroid differentiation of K562 or HEL cells. "

Related Drugs and Biologics

1.	pyrimidine