tilivalline

a pyrrolo(1,4)benzodiazepine derivative with an 11-beta-indole substituent; found in secondary metabolites of Klebsiella pneumoniae var. oxytoca; structure given in first source; RN given refers to (11S-cis)-isomer

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zechner, Ellen L: 5 articles (01/2022 - 09/2014)
2.	Högenauer, Christoph: 4 articles (01/2022 - 09/2014)
3.	Kienesberger, Sabine: 3 articles (01/2022 - 01/2019)
4.	Gorkiewicz, Gregor: 3 articles (01/2022 - 09/2014)
5.	Breinbauer, Rolf: 3 articles (01/2019 - 09/2014)
6.	Pletz, Jakob: 3 articles (01/2019 - 09/2014)
7.	Pöltl, Lisa: 2 articles (01/2022 - 01/2019)
8.	Kitsera, Maksym: 2 articles (01/2022 - 01/2019)
9.	Unterhauser, Katrin: 2 articles (01/2022 - 01/2019)
10.	Dornisch, Elisabeth: 2 articles (01/2019 - 11/2017)

Related Diseases

1.	Colitis 09/09/2014 - "The data link pyrrolobenzodiazepines to human disease and identify tilivalline as a target for diagnosis and neutralizing strategies in prevention and treatment of colitis. " 09/09/2014 - "Tilivalline induced apoptosis in cultured human cells in vitro and disrupted epithelial barrier function, consistent with the mucosal damage associated with colitis observed in human AAHC and the corresponding animal model. " 11/13/2017 - "Since the producing organism Klebsiella oxytoca is part of the intestinal microbiota and the pyrrolobenzodiazepine causes the pathogenesis of colitis it is important to understand the biosynthesis and regulation of tilivalline activity. " 09/09/2014 - "oxytoca as the pyrrolobenzodiazepine tilivalline and demonstrated its causative action in the pathogenesis of colitis in an animal model. " 01/01/2022 - "Klebsiella oxytoca is a gastrointestinal pathobiont with the potential to produce the toxins tilivalline and tilimycin, which cause antibiotic-associated hemorrhagic colitis. "
2.	Necrotizing Enterocolitis 01/01/2022 - "These closely related microbes produce the enterotoxins tilimycin and tilivalline; cytotoxin-producing strains are the causative agent of antibiotic-associated hemorrhagic colitis and have been associated with necrotizing enterocolitis of premature infants. "
3.	Leukemia L1210 03/01/1995 - "Tilivalline (TV) possesses a pyrrolo[1,4]benzodiazepine nucleus and an indole substituent in its structure, and is cytotoxic toward mouse leukemia L1210 cells. "
4.	Inflammation (Inflammations) 01/01/2022 - "In this context, we established that tilivalline, but not tilimycin, is a strong agonist of pregnane X receptor (PXR), a master regulator of xenobiotic detoxification and intestinal inflammation. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	tilimycin
3.	Peptides (Polypeptides)
4.	pyrrolo(2,1-c)(1,4)benzodiazepine
5.	Xenobiotics
6.	Enterotoxins (Enterotoxin)
7.	Cytotoxins (Cytolysins)
8.	Benzodiazepines
9.	Pregnane X Receptor
10.	indole