natsudaidain

isolated from Citrus plants; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Necrosis 01/01/2009 - "These findings suggest that natsudaidain inhibits tumour necrosis factor-alpha and cyclooxygenase-2 production by suppressing p38 MAPK phosphorylation but not p65 NFkappaB phosphorylation, and that natsudaidain might alleviate inflammatory diseases." 01/01/2009 - "On the other hand, natsudaidain dose-dependently inhibited tumour necrosis factor-alpha protein and mRNA levels in A23187-stimulated RBL-2H3 cells; a concentration of 6.8 microM was required for a 50% reduction. " 01/01/2009 - "We investigated the inhibitory effects of natsudaidain, which is a polymethoxyflavone isolated from Citrus plants, on histamine release, tumour necrosis factor-alpha production and cyclooxygenase-2 expression in Ca ionophore-stimulated rat basophilic leukemia cells (A23187-stimulated RBL-2H3 cells) by spectrofluorometric, ELISA and immunoblotting methods. "
2.	Leukemia 01/01/2009 - "We investigated the inhibitory effects of natsudaidain, which is a polymethoxyflavone isolated from Citrus plants, on histamine release, tumour necrosis factor-alpha production and cyclooxygenase-2 expression in Ca ionophore-stimulated rat basophilic leukemia cells (A23187-stimulated RBL-2H3 cells) by spectrofluorometric, ELISA and immunoblotting methods. "

1.	Cyclooxygenase 2 (Cyclooxygenase-2)
2.	p38 Mitogen-Activated Protein Kinases
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Ionophores