N 3389

antagonist of 5-HT(3) and 5-HT(4) receptors; structure given in first source

Also Known As:

3,9-dimethyl-3,9-diazabicyclo(3.3.1)non-7-yl-1H-indazole-3-carboxamide dihydrochloride; N-3389; endo-3,9-dimethyl-3,9-diazabicyclo(3.3.1)non-7-yl-1H-indazole-3-carboxamide

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198

Experts

1.	Cui, Yonghua: 1 article (01/2021)
2.	Li, Ying: 1 article (01/2021)
3.	Liu, Jingran: 1 article (01/2021)
4.	Ma, Zihan: 1 article (01/2021)
5.	Wang, Fang: 1 article (01/2021)
6.	Wen, Fang: 1 article (01/2021)
7.	Yan, Junjuan: 1 article (01/2021)
8.	Yu, Liping: 1 article (01/2021)
9.	Zhang, Jishui: 1 article (01/2021)
10.	Andersen, Stine Linding: 1 article (02/2014)

Related Diseases

1.	Hypothyroidism 02/01/2014 - "Among mothers included (n = 450 842), altogether 89,022 (19·7%) reported that they were smokers during the first pregnancy in the study period, and 8905 (2·0%) developed hyper (n = 3389)- or hypothyroidism (n = 5516) after birth of the child. "
2.	Stroke (Strokes) 12/01/2002 - "Using data from the Department of Veterans Affairs National Surgical Quality Improvement Project, we classified facilities on the basis of 30-day complications of carotid endarterectomy (stroke, myocardial infarction, death) during 1994 to 1995 (period 1, n=3389) and then compared these groups of facilities for complication rates during 1996 to 1997 (period 2, n=4453). "
3.	Tics (Tic) 01/01/2021 - "With the age growing, the use of antipsychotics was on the rise; 22% (n = 3389) were prescribed for at least two anti-tic medication, and the most common medication combination group was tiapride and TCM (33.7%), followed by CAP and TCM (22.1%). "
4.	Vomiting 03/05/1997 - "The time-course of cisplatin (10 mg/kg, i.p.)-induced emesis in another group of ferrets paralleled the increase in abdominal afferent vagus nerve activity induced by cisplatin (10 mg/kg, i.p.) and was inhibited by pretreatment with N-3389 (1.0 mg/kg, i.v.). " 03/05/1997 - "The antiemetic activity of N-3389 (endo-3,9-dimethyl-3,9-diazabicyclo[3,3,1]non-7-yl-1 H-indazole-3-carboxamide dihydrochloride), a new 5-HT3 and 5-HT4 receptor antagonist, against cisplatin-, cyclophosphamide- and copper sulfate-induced emesis was investigated using ferrets. "
5.	Myocardial Infarction 12/01/2002 - "Using data from the Department of Veterans Affairs National Surgical Quality Improvement Project, we classified facilities on the basis of 30-day complications of carotid endarterectomy (stroke, myocardial infarction, death) during 1994 to 1995 (period 1, n=3389) and then compared these groups of facilities for complication rates during 1996 to 1997 (period 2, n=4453). "

Related Drugs and Biologics

1.	Tiapride Hydrochloride
2.	5-HT4 Serotonin Receptors
3.	5-HT3 Serotonin Receptors (5 HT3 Receptor)
4.	Copper Sulfate (Sulfate, Copper)
5.	Antipsychotic Agents (Antipsychotics)
6.	Indazoles
7.	Cyclophosphamide (Cytoxan)
8.	Cisplatin (Platino)
9.	Antiemetics
10.	2-methyl-5-HT

Related Therapies and Procedures

1.	Carotid Endarterectomy