Thymex-L

a crude thymus extract; contains peptides and proteins with a molecular mass range of 2-68 kDa; the active compound is bigger than 5 kDa; potentiates the retinoic acid-induced differentiation of the human myeloid leukemia cell line HL-60

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Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Melanoma (Melanoma, Malignant) 05/01/1995 - "These results indicate that depressed monocyte functions in selected melanoma patients may be partially improved by Thymex-L." 05/01/1995 - "The influence of the thymic preparation thymex-L on deficient antitumor-activity of monocytes from melanoma patients in-vitro." 05/01/1995 - "Although the improvement of median levels of killer cell activity was found to be independent from the disease stage, the Thymex-L effect was only statistically significant in stage I and melanoma patients after chemotherapy. " 05/01/1995 - "However, after stimulation with rIFN-gamma, the median level of TNF-alpha secretion by melanoma monocytes significantly increased (about 2-fold) when preincubated with Thymex-L. "
2.	Lung Neoplasms (Lung Cancer) 09/01/1997 - "The predictive value of in vitro testing of lung cancer patients' lymphocyte responsiveness to stimulation by Thymex L. " 01/01/1992 - "In order to prevent the radiotherapeutically-induced aggravation of initial immunodeficiency, a thymic preparation (Thymex L) was given to lung cancer patients simultaneously with irradiation. " 01/01/1992 - "The protective activity of Thymex L against radiotherapeutically-induced cellular immunodepression in lung cancer patients." 09/01/1997 - "Eleven lung cancer patients were selected for combined radio and immunotherapy with a thymic agent-Thymex L. " 01/01/1992 - "Our results indicate that Thymex L can successfully prevent the harmful effect of radiation therapy on cellular immunity in a majority of lung cancer patients."
3.	Myeloid Leukemia (Leukemia, Myelocytic) 03/16/1995 - "The thymus extract Thymex-L potentiates the retinoic acid-induced differentiation of the human myeloid leukemia cell line HL-60."

Related Drugs and Biologics

1.	Phytohemagglutinins
2.	Indomethacin (Indometacin)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Tretinoin (Retinoic Acid)
5.	Thymus Extracts
6.	N 30
7.	thymomodulin

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics
3.	Immunotherapy
4.	Injections
5.	Drug Therapy (Chemotherapy)