PD 131112

PD-131112 (CI-990) is the L-alanylamide produrg of PD-131628

Also Known As:

CI-990; PD-131112; PD131112; S-(R*,R*)-7-3-(2-amino-1-oxopropyl)amino-1-pyrrolidinyl-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - PD 131112: 1

Related Diseases

1.	Infections 09/01/1995 - "Clinafloxacin, CI-990, and PD 138312 may have therapeutic potential in systemic enterococcal infections in humans." 09/01/1995 - "Oral efficacies (in milligrams per kilogram of body weight for 50% protective doses) in lethal mouse infections with quinolone-susceptible strains were 4.3 to 24 for clinafloxacin, 7.2 to 39 for CI-990, 7.2 to 76 for PD 138312, and 41 to > 100 for ciprofloxacin; when the drugs were given subcutaneously, the order was similar and values ranged from 1.1 to 12.5. "
2.	Body Weight (Weight, Body) 09/01/1995 - "Oral efficacies (in milligrams per kilogram of body weight for 50% protective doses) in lethal mouse infections with quinolone-susceptible strains were 4.3 to 24 for clinafloxacin, 7.2 to 39 for CI-990, 7.2 to 76 for PD 138312, and 41 to > 100 for ciprofloxacin; when the drugs were given subcutaneously, the order was similar and values ranged from 1.1 to 12.5. "

Related Drugs and Biologics

1.	Quinolones
2.	Ciprofloxacin (Cipro)
3.	PD 138312
4.	clinafloxacin